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ald, a recessive allele in atherosclerosis-resistant AKR inbred mice, is characterized by complete adrenocortical lipid depletion in postpubertal males, which appears to be androgen dependent. The recent observations of adrenocortical lipid depletion in male and female Acact- ± mice and the mapping of Acact to chromosome 1 (near the ald locus) prompted us to ask whether ald results from an Acact...