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Hepatitis C virus (HCV) infection remains a challenge to human public health despite the development of highly effective direct‐acting antivirals (DAAs). Sofosbuvir (SOF), a key component in most DAA‐based anti‐HCV cocktail regimens, is a potent viral RNA polymerase (NS5B) inhibitor with a high barrier to drug resistance. The serine‐to‐threonine mutation at NS5B 282 (S282T) confers the SOF resistance,...
Noise-like pulses (NLPs) are of interest as they can provide low temporal coherence, smooth and broad spectra and high brightness. Owing to these merits, NLPs can facilitate many optical sensing applications, such as hybrid interrogation of high-count low reflectivity fiber Bragg grating arrays. In this paper, we report the abnormal NLP evolution in a passively Er-doped mode-locked fibre laser, of...
This paper is reporting design and simulation of a pixelated-core large pitch optical fibre. With this new design, existence of higher order modes, mode instability at high power levels, mode shrinking and gain reduction upon bending has been solved and the bending loss is negligible in the frequently used bending radius of 3cm to 5cm. Even down to 3mm bending radius, magnitude of bending loss can...
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