Per R. Poulsen

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[OA013] Treatment accuracy in surface guided deep-inspiration breath-hold radiotherapy for left-sided breast cancer

Esben Worm, Birgitte Offersen, Per R. Poulsen, Ellen Askholm, more

Physica Medica > 2018 > 52 > S1 > 5-6

To evaluate the setup accuracy and intrafraction stability in deep-inspiration breath-hold (DIBH) surface guided radiotherapy (SGRT) for left-sided breast cancer.Five patients received 15 (n = 4) or 18 (n = 1) fractions of radiotherapy for left-sided breast cancer. Treatment planning was based on two opposing fields, aligned tangentially to the thoracic wall. At treatment, patient setup was initially...

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Fiducial marker guided stereotactic liver radiotherapy: Is a time delay between marker implantation and planning CT needed?

Esben S. Worm, Jenny Bertholet, Morten Høyer, Walther Fledelius, more

Radiotherapy and Oncology > 2016 > 121 > 1 > 75-78

To minimize the risk of marker migration in fiducial marker guided liver SBRT it is common to add a delay of a week between marker implantation and planning CT. This study found that such a delay is unnecessary and could be avoided to minimize the treatment preparation time.

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Time-Resolved Intrafraction Target Translations and Rotations During Stereotactic Liver Radiation Therapy: Implications for Marker-based Localization Accuracy

Jenny Bertholet, Esben S. Worm, Walther Fledelius, Morten Høyer, more

International Journal of Radiation Oncology*Biology*Physics > 2016 > 95 > 2 > 802-809

Image guided liver stereotactic body radiation therapy (SBRT) often relies on implanted fiducial markers. The target localization accuracy decreases with increased marker-target distance. This may occur partly because of liver rotations. The aim of this study was to examine time-resolved translations and rotations of liver marker constellations and investigate if time-resolved intrafraction rotational...

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Real-Time 3D Image Guidance Using a Standard LINAC: Measured Motion, Accuracy, and Precision of the First Prospective Clinical Trial of Kilovoltage Intrafraction Monitoring–Guided Gating for Prostate Cancer Radiation Therapy

Paul J. Keall, Jin Aun Ng, Prabhjot Juneja, Ricky T. O'Brien, more

International Journal of Radiation Oncology*Biology*Physics > 2016 > 94 > 5 > 1015-1021

Kilovoltage intrafraction monitoring (KIM) is a new real-time 3-dimensional image guidance method. Unlike previous real-time image guidance methods, KIM uses a standard linear accelerator without any additional equipment needed. The first prospective clinical trial of KIM is underway for prostate cancer radiation therapy. In this paper we report on the measured motion accuracy and precision using...

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Multileaf Collimator Tracking Improves Dose Delivery for Prostate Cancer Radiation Therapy: Results of the First Clinical Trial

Emma Colvill, Jeremy T. Booth, Ricky T. O'Brien, Thomas N. Eade, more

International Journal of Radiation Oncology*Biology*Physics > 2015 > 92 > 5 > 1141-1147

To test the hypothesis that multileaf collimator (MLC) tracking improves the consistency between the planned and delivered dose compared with the dose without MLC tracking, in the setting of a prostate cancer volumetric modulated arc therapy trial.Multileaf collimator tracking was implemented for 15 patients in a prostate cancer radiation therapy trial; in total, 513 treatment fractions were delivered...

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Three-dimensional, Time-Resolved, Intrafraction Motion Monitoring Throughout Stereotactic Liver Radiation Therapy on a Conventional Linear Accelerator

Esben S. Worm, Morten Høyer, Walter Fledelius, Per R. Poulsen

International Journal of Radiation Oncology, Biology, Physics > 2013 > 86 > 1 > 190-197

To investigate the time-resolved 3-dimensional (3D) internal motion throughout stereotactic body radiation therapy (SBRT) of tumors in the liver using standard x-ray imagers of a conventional linear accelerator.Ten patients with implanted gold markers received 11 treatment courses of 3-fraction SBRT in a stereotactic body-frame on a conventional linear accelerator. Two pretreatment and 1 posttreatment...

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Kilovoltage Intrafraction Monitoring for Prostate Intensity Modulated Arc Therapy: First Clinical Results

Jin Aun Ng, Jeremy T. Booth, Per R. Poulsen, Walther Fledelius, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 84 > 5 > e655-e661

Most linear accelerators purchased today are equipped with a gantry-mounted kilovoltage X-ray imager which is typically used for patient imaging prior to therapy. A novel application of the X-ray system is kilovoltage intrafraction monitoring (KIM), in which the 3-dimensional (3D) tumor position is determined during treatment. In this paper, we report on the first use of KIM in a prospective clinical...

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On-Line Use of Three-Dimensional Marker Trajectory Estimation From Cone-Beam Computed Tomography Projections for Precise Setup in Radiotherapy for Targets With Respiratory Motion

Esben S. Worm, Morten Høyer, Walther Fledelius, Jens E. Nielsen, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 83 > 1 > e145-e151

To develop and evaluate accurate and objective on-line patient setup based on a novel semiautomatic technique in which three-dimensional marker trajectories were estimated from two-dimensional cone-beam computed tomography (CBCT) projections.Seven treatment courses of stereotactic body radiotherapy for liver tumors were delivered in 21 fractions in total to 6 patients by a linear accelerator. Each...

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Megavoltage Image-Based Dynamic Multileaf Collimator Tracking of a NiTi Stent in Porcine Lungs on a Linear Accelerator

Per R. Poulsen, Jesper Carl, Jane Nielsen, Martin S. Nielsen, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 82 > 2 > e321-e327

To investigate the accuracy and potential limitations of MV image-based dynamic multileaf collimator (DMLC) tracking in a porcine model on a linear accelerator.A thermo-expandable NiTi stent designed for kilovoltage (kV) X-ray visualization of lung lesions was inserted into the bronchia of three anaesthetized Göttingen minipigs. A four-dimensional computed tomography scan was used for planning a five-field...

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First Demonstration of Combined kV/MV Image-Guided Real-Time Dynamic Multileaf-Collimator Target Tracking

Byungchul Cho, Per R. Poulsen, Alex Sloutsky, Amit Sawant, more

International Journal of Radiation Oncology, Biology, Physics > 2009 > 74 > 3 > 859-867

For intrafraction motion management, a real-time tracking system was developed by combining fiducial marker-based tracking via simultaneous kilovoltage (kV) and megavoltage (MV) imaging and a dynamic multileaf collimator (DMLC) beam-tracking system.The integrated tracking system employed a Varian Trilogy system equipped with kV/MV imaging systems and a Millennium 120-leaf MLC. A gold marker in elliptical...

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Search results for: Per R. Poulsen

[OA013] Treatment accuracy in surface guided deep-inspiration breath-hold radiotherapy for left-sided breast cancer

Fiducial marker guided stereotactic liver radiotherapy: Is a time delay between marker implantation and planning CT needed?

Time-Resolved Intrafraction Target Translations and Rotations During Stereotactic Liver Radiation Therapy: Implications for Marker-based Localization Accuracy

Real-Time 3D Image Guidance Using a Standard LINAC: Measured Motion, Accuracy, and Precision of the First Prospective Clinical Trial of Kilovoltage Intrafraction Monitoring–Guided Gating for Prostate Cancer Radiation Therapy

Multileaf Collimator Tracking Improves Dose Delivery for Prostate Cancer Radiation Therapy: Results of the First Clinical Trial

Three-dimensional, Time-Resolved, Intrafraction Motion Monitoring Throughout Stereotactic Liver Radiation Therapy on a Conventional Linear Accelerator

Kilovoltage Intrafraction Monitoring for Prostate Intensity Modulated Arc Therapy: First Clinical Results

On-Line Use of Three-Dimensional Marker Trajectory Estimation From Cone-Beam Computed Tomography Projections for Precise Setup in Radiotherapy for Targets With Respiratory Motion

Megavoltage Image-Based Dynamic Multileaf Collimator Tracking of a NiTi Stent in Porcine Lungs on a Linear Accelerator

First Demonstration of Combined kV/MV Image-Guided Real-Time Dynamic Multileaf-Collimator Target Tracking

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