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Aims
To compare long‐term outcomes among participants randomized to buprenorphine or methadone.
Design, Setting and Participants
Follow‐up was conducted in 2011–14 of 1080 opioid‐dependent participants entering seven opioid treatment programs in the United States between 2006 and 2009 and randomized (within each program) to receive open‐label buprenorphine/naloxone or methadone for up to 24 weeks;...
AimsTo estimate mortality rates among treated opioid‐dependent individuals by cause and in relation to the general population, and to estimate the instantaneous effects of opioid detoxification and maintenance treatment (MMT) on the hazard of all‐cause and cause‐specific mortality.
DesignPopulation‐based treatment cohort study.
SettingLinked mortality data on all individuals first enrolled in publicly...
California treats the largest population of opioid dependent individuals in the USA and is among a small group of states that applies regulations for opioid treatment that are more stringent than existing federal regulations. We aim to characterize changes in patient characteristics and treatment utilization over time, and identify determinants of successful completion of detoxification and MMT retention...
Aims To identify dose‐tapering strategies associated with sustained success following methadone maintenance treatment (MMT).
Design Population‐based retrospective cohort study.
Setting Linked administrative medication dispensation data from British Columbia, Canada.
Participants From 25 545 completed MMT episodes, 14 602 of which initiated a taper, 4183 individuals (accounting for 4917 MMT episodes)...
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