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The purpose of this study was to design a new stable liposomal formulation for the anticancer drug idarubicin. Idarubicin is a relatively hydrophobic member of the anthracycline family. It exhibits pronounced bilayer interactions leading to rapid in vivo drug release from liposomes. This rapid drug leakage is due to the presence of cholesterol and charged lipids in the liposomal bilayer. Therefore,...
The antioxidant properties of rye bran alkylresorcinols (C15:0–C25:0) and extracts from whole-grain cereal products were evaluated using their radical-scavenging activity on DPPH and the chemiluminescence method (CL). DPPH radical reduction varied from ∼10% to ∼60% for the alkylresorcinol homologues at concentrations from 5 to 300μM and was not dependent on the length of the alkyl side chain of the...
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