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Therapeutic exposure to ionising radiation can induce normal tissue side effects which consistently differ among individuals suggesting a possible genetic control. One approach to elucidate the underlying mechanisms is to analyse the relation between genetic traits, biomarkers of in vitro DNA damage and side toxicity in vivo.43 breast cancer (BC) patients receiving radiotherapy after a breast-conserving...
Purpose This study aimed to assess whether haplotypes in XRCC1 and SNPs in OGG1 and XRCC3 were associated with an increased risk of developing breast cancer (BC) and early adverse reactions after radiotherapy. Methods 43 Italian breast cancer patients and 31 healthy controls were genotyped for XRCC1(−77T→C,194,399), OGG1-326 and XRCC3-241 by RFLP–PCR. Results XRCC1-77T→C, XRCC1-194, OGG1 and XRCC3...
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