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The molecular mechanism of lipoprotein binding by the low‐density lipoprotein (LDL) receptor (LDLR) is poorly understood, one reason being that structures of lipoprotein–receptor complexes are not available. LDLR uses calcium‐binding repeats (LRs) to interact with apolipoprotein B and apolipoprotein E (ApoB and ApoE). We have used NMR and SPR to characterize the complexes formed by LR5 and three peptides...
Peptidyl–prolyl isomerases (PPIases) are emerging as key regulators of many diverse biological processes. Elucidating the role of PPIase activity in vivo has been challenging because mutagenesis of active-site residues not only reduces the catalytic activity of these enzymes but also dramatically affects substrate binding. Employing the cyclophilin A PPIase together with its biologically relevant...
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