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We investigated two genetic polymorphisms in the tumor necrosis factor locus (TNF-α -308 G->A and LT-α +252 A->G) as risk factors for coronary atherothrombotic disease (CAD) by determining its prevalence in 148 survivors of myocardial infarction (MI) with angiographically-proven severe CAD, and in 148 age-, gender- and race-matched controls. The odds ratio (OR) for MI related to the mutant TNF-α...