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Chronic in vivo treatment with opioid antagonists increases opioid receptor density and the potency of opioid agonists without altering receptor mRNA levels. To determine if basal receptor density affects opioid receptor upregulation, we examined the effect of chronic naltrexone treatment on μ-opioid receptor density and mRNA in two mice strains that differ in μ-opioid receptor density. CXBK mice...
Regulation of the μ-opioid receptor gene by opioid analgesic drugs has not been observed in rats and mice following in vivo treatments that produce tolerance. Although in vivo heterologous regulation of μ-opioid receptor mRNA by non-opioid compounds has been reported, the failure to observe changes in μ-opioid receptor mRNA levels in vivo after treatment with opioid agonists raised the possibility...
Recent studies suggest substantial interactions between opioids and ethanol (EtOH). Both in vivo and in vitro experiments indicate that EtOH can regulate opioid systems and that opioids can modify EtOH consumption. In the present studies, we examined if EtOH consumption altered opioid receptors and the potency of opioid analgesics. Mice were given unlimited access to 6-7% EtOH alone for 7 days...
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