Search results for: Sebastian Longen

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article

Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis

Ahmed Aglan, Sebastian Longen, Nathalie Dehne, Yvette Köhler, more

Journal of Molecular Medicine > 2017 > 95 > 3 > 257-271

Renal mesangial cells are regarded as main players in glomerular inflammatory diseases. To investigate a possible crosstalk between inflammatory and hypoxia-driven signaling processes, we stimulated cultured mouse mesangial cells with different inflammatory agents and analyzed the expression of prolyl hydroxylase domain containing proteins (PHDs), the main regulators of hypoxia-inducible factor (HIF)...

article

H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases

Sebastian Longen, Karl-Friedrich Beck, Josef Pfeilschifter

Pharmacological Research > 2016 > 111 > C > 642-651

During the last decades, small inorganic molecules like reactive oxygen species (ROS), nitric oxide (NO), carbon monoxide (CO) and even the highly toxic hydrogen sulfide (H₂S) have been evolved as important signaling molecules that trigger crucial cellular processes by regulating the activity of kinases, phosphatases and transcription factors. These redox molecules use similar target structures and...

article

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain

Katharina M.J. Syhr, Meike Boosen, Stephan W. Hohmann, Sebastian Longen, more

Brain Research > 2015 > 1624 > C > 380-389

Accumulating lines of evidence indicate that hydrogen sulfide (H₂S) contributes to the processing of chronic pain. However, the sources of H₂S production in the nociceptive system are poorly understood. Here we investigated the expression of the H₂S releasing enzyme cystathionine γ-lyase (CSE) in the nociceptive system and characterized its role in chronic pain signaling using CSE deficient mice....

article

Proteomic analysis of cysteine persulfides in hydrogen sulfide-dependent signaling

Sebastian Longen, Florian Richter, Karl-Friedrich Beck, Ilka Wittig, more

Nitric Oxide > 2015 > 47 > Supplement > S24

article

Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells

Karl-Friedrich Beck, Johannes Euler, Florian Eisel, Martina Beck, more

Biochemical Pharmacology > 2015 > 93 > 3 > 362-369

Glomerular mesangial cells are smooth muscle cell-like pericytes and are regarded as key players in kidney diseases. In an inflammatory setting, these cells produce high amounts of inflammatory cytokines, chemokines and redox mediators such as reactive oxygen species or nitric oxide (NO). The temporal production of ROS, NO and other redox mediators markedly contributes to the final outcome of inflammatory...

article

The Disulfide Relay of the Intermembrane Space Oxidizes the Ribosomal Subunit Mrp10 on Its Transit into the Mitochondrial Matrix

Sebastian Longen, Michael W. Woellhaf, Carmelina Petrungaro, Jan Riemer, more

Developmental Cell > 2014 > 28 > 1 > 30-42

Most mitochondrial proteins are synthesized in the cytosol and directed into the organelle; matrix proteins contain presequences that guide them through translocases in contact sites of the outer and inner membrane. In contrast, the import of many intermembrane space proteins depends on cysteine residues and the oxidoreductase Mia40. Here, we show that both import machineries can cooperate in the...

article

Oxidation-driven protein import into the intermembrane space of mitochondria

Johannes M. Herrmann, Daniel Weckbecker, Sebastian Longen, Jan Riemer

BBA - Bioenergetics > 2012 > 1817 > Supplement > S32-S33

article

Oxidative protein folding in the intermembrane space of mitochondria

Melanie Bien, Manuel Fischer, Sebastian Longen, Johannes M. Herrmann, more

BBA - Bioenergetics > 2010 > 1797 > Supplement > 109

article

Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione

Melanie Bien, Sebastian Longen, Nikola Wagener, Ilona Chwalla, more

Molecular Cell > 2010 > 37 > 4 > 516-528

The disulfide relay system in the intermembrane space of mitochondria is of crucial importance for mitochondrial biogenesis. Major players in this pathway are the oxidoreductase Mia40 that oxidizes substrates and the sulfhydryl oxidase Erv1 that reoxidizes Mia40. To analyze in detail the mechanism of this oxidative pathway and the interplay of its components, we reconstituted the complete process...

article

Systematic Analysis of the Twin Cx9C Protein Family

Sebastian Longen, Melanie Bien, Karl Bihlmaier, Christine Kloeppel, more

Journal of Molecular Biology > 2009 > 393 > 2 > 356-368

The Mia40–Erv1 disulfide relay system is of high importance for mitochondrial biogenesis. Most so far identified substrates of this machinery contain either two cysteine-x ₃ -cysteine (twin Cx ₃ C) or two cysteine-x ₉ -cysteine (twin Cx ₉ C) motifs. While the first group is composed of well-characterized components of the mitochondrial import machinery, the molecular...

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Keywords

HYDROGEN SULFIDE (2)
MESANGIAL CELLS (2)
NITRIC OXIDE (2)
CHRONIC PAIN (1)
CSE (1)
CTH (1)
CYTOKINES (1)
DORSAL ROOT GANGLIA (1)
ERV1 (1)
HYDROPERSULFIDE (1)
KNOCKOUT MICE (1)
MIA40 (1)
MITOCHONDRIA (1)
PEROXYNITRITE (1)
PKA (1)
PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN 3 (1)
PROTEINS (1)
RESPIRATION (1)
THIOL-BASED REDOX SWITCHES (1)
TWIN CX9C PROTEINS (1)
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Elsevier (9)
Springer (1)

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Search results for: Sebastian Longen

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