Search results for: Emma L. Burrows

Items from 1 to 11 out of 11 results

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Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks

Claire Salmon, Shuting Li, Emma L. Burrows, Katherine A. Johnson

Journal of Neurochemistry > 168 > 9 > 2170 - 2189

Atypical sustained attention is a symptom in a number of neurological and psychological conditions. Investigations into its neural underpinnings are required for improved management and treatment. Rodents are useful in investigating the neurobiology underlying atypical sustained attention and several rodent tasks have been developed for use in touchscreen testing platforms that mimic methodology used...

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Mice with an autism‐associated R451C mutation in neuroligin‐3 show a cautious but accurate response style in touchscreen attention tasks

Emma L. Burrows, Carlos May, Thomas Hill, Leonid Churliov, more

Genes, Brain and Behavior > 21 > 1 > n/a - n/a

One of the earliest identifiable features of autism spectrum disorder (ASD) is altered attention. Mice expressing the ASD‐associated R451C mutation in synaptic adhesion protein neuroligin‐3 (NL3) exhibit impaired reciprocal social interactions and repetitive and restrictive behaviours. The role of this mutation in attentional abnormalities has not been established. We assessed attention in male NL3...

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Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behaviours

Amy Shepherd, Carlos May, Leonid Churilov, Paul A. Adlard, more

Genes, Brain and Behavior > 20 > 1 > n/a - n/a

While Alzheimer's disease (AD) is traditionally associated with deficits in episodic memory, early changes in other cognitive domains, such as attention, have been gaining interest. In line with clinical observations, some animal models of AD have been shown to develop attentional deficits, but this is not consistent across all models. The APPswe/PS1ΔE9 (APP/PS1) mouse is one of the most commonly...

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ABSENCE OF TASK LEARNING IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER’S DISEASE AS MEASURED BY TRANSLATABLE TOUCHSCREEN TECHNOLOGY

Amy L. Shepherd, Anthony J. Hannan, Emma L. Burrows

Alzheimer's & Dementia > 2017 > 13 > 7(S) > P632

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Environmental enrichment enhances cognitive flexibility in C57BL/6 mice on a touchscreen reversal learning task

Ariel Zeleznikow-Johnston, Emma L. Burrows, Thibault Renoir, Anthony J. Hannan

Neuropharmacology > 2017 > 117 > C > 219-226

Environmental enrichment (EE) is any positive modification of the ‘standard housing’ (SH) conditions in which laboratory animals are typically held, usually involving increased opportunity for cognitive stimulation and physical activity. EE has been reported to enhance baseline performance of wild-type animals on traditional cognitive behavioural tasks. Recently, touchscreen operant testing chambers...

article

Cognitive endophenotypes, gene–environment interactions and experience-dependent plasticity in animal models of schizophrenia

Emma L. Burrows, Anthony J. Hannan

Biological Psychology > 2016 > 116 > C > 82-89

Schizophrenia is a devastating brain disorder caused by a complex and heterogeneous combination of genetic and environmental factors. In order to develop effective new strategies to prevent and treat schizophrenia, valid animal models are required which accurately model the disorder, and ideally provide construct, face and predictive validity. The cognitive deficits in schizophrenia represent some...

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Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications

Gursharan Chana, Liliana Laskaris, Christos Pantelis, Piers Gillett, more

Brain Behavior and Immunity > 2015 > 49 > Complete > 197-205

Metabotropic glutamate receptor 5 (mGluR5) and microglial abnormalities have been implicated in autism spectrum disorder (ASD). However, controversy exists as to whether the receptor is down or upregulated in functioning in ASD. In addition, whilst activation of mGluR5 has been shown to attenuate microglial activation, its role in maintaining microglial homeostasis during development has not been...

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A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice

Emma L. Burrows, Liliana Laskaris, Lynn Koyama, Leonid Churilov, more

Molecular Autism > 2015 > 6 > 1 > 1-11

Background Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in social communication and repetitive behavior. Risperidone, an atypical antipsychotic, is widely used to treat aggression in ASD. In order to understand the neurobiological underpinnings of these challenging behaviors, a thorough characterisation of behavioral endophenotypes...

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Identifying novel interventional strategies for psychiatric disorders: integrating genomics, ‘enviromics’ and gene–environment interactions in valid preclinical models

Caitlin E McOmish, Emma L Burrows, Anthony J Hannan

British Journal of Pharmacology > 171 > 20 > 4719 - 4728

Psychiatric disorders affect a substantial proportion of the population worldwide. This high prevalence, combined with the chronicity of the disorders and the major social and economic impacts, creates a significant burden. As a result, an important priority is the development of novel and effective interventional strategies for reducing incidence rates and improving outcomes. This review explores...

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Increased adult hippocampal neurogenesis and abnormal migration of adult‐born granule neurons is associated with hippocampal‐specific cognitive deficits in phospholipase C‐β1 knockout mice

Elizabeth E. Manning, Mark I. Ransome, Emma L. Burrows, Anthony J. Hannan

Hippocampus > 22 > 2 > 309 - 319

Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia‐like endophenotypes in phospholipase C‐β1 knockout (PLC‐β1^−/−) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC‐β1 signals via multiple G‐protein coupled receptor pathways implicated in neural cellular plasticity; however, adult...

article

Gene–environment interactions and construct validity in preclinical models of psychiatric disorders

Emma L. Burrows, Caitlin E. McOmish, Anthony J. Hannan

Progress in Neuropsychopharmacology & Biological Psychiatry > 2011 > 35 > 6 > 1376-1382

The contributions of genetic risk factors to susceptibility for brain disorders are often so closely intertwined with environmental factors that studying genes in isolation cannot provide the full picture of pathogenesis. With recent advances in our understanding of psychiatric genetics and environmental modifiers we are now in a position to develop more accurate animal models of psychiatric disorders...

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