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This paper presents a current control method for totem-pole PFC-rectifiers which avoids the need for expensive sensing circuits. The design makes use of only one switch current as current feedback signal. The control method is based on a detection algorithm for conduction mode detection in mixed conduction mode (MCM) operation. Using a DSP the mode detection is calculated on-line and based on the...
Differentiated pancreatic acinar cells expressing endogenous levels of mutant K-Ras do not spontaneously develop pancreatic ductal adenocarcinoma (PDAC). However, we hypothesized that acinar cells would develop PDAC in the presence of Ras activity levels mimicking those of human tumor cells.We measured Ras activity in PDAC cells from mice and humans using a Raf pull-down assay. We compared the effects...
Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults.We therefore studied expression and function of key organic anion transporters and their transactivators in 8-week-old obese Zucker rats, an established model for non-alcoholic fatty liver disease.Compared to their heterozygous littermates, obese animals showed a significant reduction in...
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