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Stimulating new blood vessel growth in ischemic hearts or limbs is a hopeful new approach for patients with advanced vascular disease. This approach is based generally upon the hypothesis that sufficient exposure of a vascular bed to an angiogenic protein will stimulate neovascularization. Most angiogenic proteins have a markedly short serum half-life. To overcome this, researchers have turned to...
Substances that increase intracellular calcium ([Ca 2+ ] i ), such as potassium chloride and serotonin, are known to induce vascular smooth muscle (VSM) contraction. One form of nitric oxide synthase, which converts l-arginine to nitric oxide, exists as a Ca 2+ -calmodulin dependent enzyme. The objective of this study was to determine whether agonists that induce VSM contraction...
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