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The cytokine IL-17 came into prominence a decade ago with the discovery of Th17 cells. IL-17 signals through its receptor to control immune responses to extracellular pathogens, particularly fungi. Conversely, IL-17 activates pathology in many autoimmune and infectious settings. Therefore, constraint of the IL-17 receptor pathway is an essential facet of its regulation. To date, our understanding...
Disseminated candidiasis is a life threatening nosocomial infection with 40–60% mortality. Fatality from candidiasis is due to fungal invasion of the kidney leading to renal failure. IL-17 is a key cytokine important in the defense against candidiasis, but mechanisms of IL-17-mediated renal immunity remain unexplored. We studied the mechanism of renal protection offered by IL-17 in an intravenous...