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Sensitivity to anoxia varies tremendously among phyla and species. Most mammals are exquisitely sensitive to low concentrations of inspired oxygen, while some fish, turtles and crustacea are very resistant. To determine the basis of anoxia tolerance, it would be useful to utilize a model system which can yield mechanistic answers. We studied the fruit fly, Drosophila melanogaster, to determine its...
Using PCR, glucose transporter-3 (GLUT3) was cloned in its entirety from rat brain. The similarity between human, murine and rodent glucose transporter-3 proteins exceeds 90%. Such extensive sequence conservation suggests that essentially all regions of the protein, including the transmembrane domains, are functionally important. This clone can be used to study GLUT3 expression in the rat by Northern...
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