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To investigate the natural course of progression of ocular motor signs in patients with progressive supranuclear palsy (PSP).114 patients with a possible or probable PSP following NINDS-SPSP criteria seen at the Department of Neurology and the German Center for Vertigo and Balance Disorders (LMU, Munich) were included in this retrospective study. All patients underwent a structured neuro-ophthalmological...
It is believed that glycogen synthase kinase‐3 (GSK‐3) hyperphosphorylates tau protein in progressive supranuclear palsy (PSP). The Tau Restoration on PSP (TAUROS) study was a double‐blind, placebo‐controlled, randomized trial to assess the efficacy, safety, and tolerability of tideglusib, a GSK‐3 inhibitor, as potential treatment for PSP. The study enrolled 146 PSP patients with mild‐to‐moderate...
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