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•Lymphocytosis in gain of function (GOF) CARD11 mutation is not always detectable at early age.•Lymphocytosis diminishes towards adulthood.•Lack of NKT cells may play a role in Epstein Barr viremia in GOF CARD11 mutation.•TCRαβ+CD4−CD8− double negative T cells are elevated in GOF CARD11 mutation.
Puumala virus (PUUV) causes an acute hemorrhagic fever with renal syndrome (HFRS), a zoonosis also called nephropathia epidemica (NE). The reservoir host of PUUV is the bank vole (Myodes glareolus). Herein we review the main clinical manifestations of NE, acute kidney injury, increased vascular permeability, coagulation abnormalities as well as pulmonary, cardiac, central nervous system and ocular...
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