Search results for: Aurora Daniele

Items from 1 to 20 out of 32 results

article

Dietary influence on adiponectin in patients with type 2 diabetes

Lutgarda Bozzetto, Rita Polito, Ersilia Nigro, Anna Prinster, more

European Journal of Clinical Investigation > 51 > 8 > n/a - n/a

Background Here, we evaluate the effects of a diet rich in low‐glycaemic index carbohydrates and fibre (CHO/Fibre diet) or monounsaturated fatty acids (MUFA diet), on fasting and postprandial adiponectin concentrations and their relationship with the beneficial effects of the experimental diets on postprandial glucose metabolism and liver fat in type 2 diabetes (T2D). Methods Fasting and postprandial...

article

microRNA‐377‐3p downregulates the oncosuppressor T‐cadherin in colorectal adenocarcinoma cells

Armando Di Palo, Chiara Siniscalchi, Rita Polito, Ersilia Nigro, more

Cell Biology International > 45 > 8 > 1797 - 1803

Colorectal cancer (CRC) is the second leading cause of death of malignant tumors worldwide. Recent studies point to a role for the adiponectin‐receptor axis in colorectal carcinogenesis, and in particular to the oncosuppressive properties of the T‐cadherin receptor. In addition, the loss of T‐cadherin expression in tumor tissues has been linked to cancer progression and attributed to aberrant methylation...

article

Supervised physical exercise improves clinical, anthropometric and biochemical parameters in adult cystic fibrosis patients: A 2‐year evaluation

Ausilia Elce, Ersilia Nigro, Monica Gelzo, Paola Iacotucci, more

The Clinical Respiratory Journal > 12 > 7 > 2228 - 2234

Objective Cystic fibrosis (CF) is the most common inherited, life limiting condition among Caucasians. No healing therapy is currently available for patients with CF. The aim of the study was to define clinical, anthropometric and biochemical effects of regular, supervised physical exercise in a large cohort of patients with CF. Materials and Methods Fifty‐nine adult patients with CF that performed...

article

Sports training and adaptive changes

Francesco Sessa, Giovanni Messina, Anna Valenzano, Antonietta Messina, more

Sport Sciences for Health > 2018 > 14 > 3 > 705-708

Purpose Sports training and professional experience lead to changes in the human motor cortex and on the autonomic nervous system. This experimental study aims to investigate as sport activities can lead changes on the human motor cortex and on the autonomic nervous system (ANS), analyzing the Heart Rate changes and spontaneous Galvanic Skin Response (GSR) fluctuations in relation to the adaptive...

article

Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells

Michela Illiano, Ersilia Nigro, Luigi Sapio, Ilaria Caiafa, more

Pulmonary Pharmacology & Therapeutics > 2017 > 45 > C > 114-120

Adipokines are known to play a relevant role in a number of cancer related molecular pathways. Adiponectin is a major adipokine with anti-inflammatory and beneficial metabolic actions. Furthermore, it has been shown to exert anti-carcinogenic effects in various tumor models and some clinical studies suggested an inverse relationship between circulating levels of adiponectin and an increased risk for...

article

PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players

Olga Scudiero, Ersilia Nigro, Ausilia Elce, Viviana Izzo, more

Sport Sciences for Health > 2017 > 13 > 2 > 395-401

Background Response to exercise is regulated by environmental factors and genetic predisposition. PPARγ and ADRB3 genes are associated with body composition. Adipose and muscle tissues secrete adipokines and myokines involved in energy expenditure; among the others, adiponectin and Irisin were associated with benefits of physical activity. Aims Here we investigate two common variants in PPARγ and...

article

Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance

Ersilia Nigro, Olga Scudiero, Maria Ludovica Monaco, Rita Polito, more

Cytokine > 2017 > 94 > C > 8-13

Adiponectin (Acrp30), its high molecular weight (HMW) oligomers, and Irisin are molecules involved in several metabolic processes. To investigate if these cytokines could represent new metabolic markers, we evaluated the expression of Acrp30 and Irisin in serum of obese children from South Italy affected by different degrees of insulin resistance (IR). The anthropometric and metabolic features were...

article

Host defense peptide‐derived privileged scaffolds for anti‐infective drug discovery

Ersilia Nigro, Irene Colavita, Daniela Sarnataro, Olga Scudiero, more

Journal of Peptide Science > 23 > 4 > 303 - 310

‘Privileged scaffolds’ are molecular frameworks which have been successfully exploited for small molecule drug discovery. Peptide privileged scaffolds, featuring a strictly conserved multiple‐disulfide framework and high variability in the rest of the sequence, display a broad range of biological effects, including antimicrobial and antiviral activity. Unlike small molecules, however, the cost of...

article

The burden of obesity in asthma and COPD: Role of adiponectin

Andrea Bianco, Ersilia Nigro, Maria Ludovica Monaco, Maria Gabriella Matera, more

Pulmonary Pharmacology & Therapeutics > 2017 > 43 > C > 20-25

The influence of obesity on development, severity and prognosis of both asthma and COPD is attracting growing interest. The impact of obesity on the respiratory system ranges from structural modifications (decline of total lung capacity) to humoral alterations. Adipose tissue strongly contributes to the establishment of an inflammatory state being an important source of adipokines. Amongst adipokines,...

article

Evaluation of adiponectin profile in Italian patients affected by obstructive sleep apnea syndrome

Donato Lacedonia, Ersilia Nigro, Maria Gabriella Matera, Olga Scudiero, more

Pulmonary Pharmacology & Therapeutics > 2016 > 40 > C > 104-108

Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder; obesity represents a major risk factor for the development and progression of OSAS although obese patients do not necessarily suffer from OSAS. Adipose tissue communicates with lung in both physiologic and pathologic conditions through the production of adipokines, hormones active in metabolic and inflammatory processes. To explore...

article

Gene molecular analysis and Adiponectin expression in professional Water Polo players

Ersilia Nigro, Dino Sangiorgio, Olga Scudiero, Maria Ludovica Monaco, more

Cytokine > 2016 > 81 > C > 88-93

Metabolic Syndrome prevalence has reaching epidemic proportions worldwide. Adiponectin (Acrp30), and in particular its High Molecular Weight (HMW) oligomers, contributes to enhance insulin sensitivity and to reduce inflammation levels. Physical exercise improves body’s biochemical balance and metabolism resulting effective in prevention of metabolic diseases. Whether improvement of metabolic features...

article

Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation

Ersilia Nigro, Maria Matteis, Fiorentina Roviezzo, Valentina Mattera Iacono, more

Pharmacological Research > 2016 > 103 > C > 114-122

Epidemiological data suggest that obesity represent an important risk factor for asthma, but the link between excess fat and airway hyperresponsiveness (AHR) and inflammation is not fully understood. Recently, a key role in physiopathologic conditions of lungs has been given to adiponectin (Acrp30). Acrp30 is one of the most expressed adipokines produced and secreted by adipose tissue, showing an...

article

Membrane Protein 4F2/CD98 Is a Cell Surface Receptor Involved in the Internalization and Trafficking of Human β-Defensin 3 in Epithelial Cells

Irene Colavita, Ersilia Nigro, Daniela Sarnataro, Olga Scudiero, more

Chemistry & Biology > 2015 > 22 > 2 > 217-228

Human β-defensins play a pivotal role in the innate immune response. Although expressed by and acting at epithelial surfaces, little is known about their specific interaction with epithelial structures. Here, we identify the transmembrane protein CD98 as a cell surface receptor involved in the internalization of human β-defensin 3 (hBD3) in human epithelial A549 cells. CD98 and hBD3 extensively colocalize...

article

Pituitary function and morphology in Fabry disease

Luigi Maione, Fabio Tortora, Roberta Modica, Valeria Ramundo, more

Endocrine > 2015 > 50 > 2 > 483-488

Endocrine abnormalities are known to affect patients with Fabry disease (FD). Pituitary gland theoretically represents an ideal target for FD because of high vascularization and low proliferation rate. We explored pituitary morphology and function in a cohort of FD patients through a prospectic, monocentric study at an Academic Tertiary Center. The study population included 28 FD patients and 42 sex...

article

Long-term follow-up of patients with phenylketonuria treated with tetrahydrobiopterin: a seven years experience

Iris Scala, Daniela Concolino, Roberto Della Casa, Anna Nastasi, more

Orphanet Journal of Rare Diseases > 2015 > 10 > 1 > 1-12

Background Phenylketonuria (PKU) is an autosomal recessive disorder caused by the deficiency of phenylalanine hydroxylase that catalyzes the conversion of phenylalanine to tyrosine, using tetrahydrobiopterin (BH4) as coenzyme. Besides dietary phenylalanine restriction, new therapeutic options are emerging, such as the treatment with BH4 in subgroups of PKU patients responding to a loading test...

article

Late diagnosis of Fabry disease caused by a de novo mutation in a patient with end stage renal disease

Antonio Pisani, Aurora Daniele, Carmela Domenico, Ersilia Nigro, more

BMC Research Notes > 2015 > 8 > 1 > 1-4

Background We present the case of a white 35-year-old male with a diagnosis of Fabry disease and negative family history. Case presentation At the age of 31, he underwent a renal biopsy with a diagnosis of hypertension-induced nephroangiosclerosis. At the age of 35, he was referred to our hospital and started dialysis: the unusual finding of left ventricular hypertrophy with a normal ejection fraction...

article

Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma

Carola Porcile, Erika Di Zazzo, Maria Ludovica Monaco, Giorgia D'Angelo, more

Journal of Cellular Physiology > 229 > 10 > 1444 - 1454

Adiponectin (Acrp30) is an adipocyte‐secreted hormone with pleiotropic metabolic effects, whose reduced levels were related to development and progression of several malignancies. We looked at the presence of Acrp30 receptors in human glioblastomas (GBM), hypothesizing a role for Acrp30 also in this untreatable cancer. Here we demonstrate that human GBM express Acrp30 receptors (AdipoR1 and AdipoR2),...

article

Altered brain protein expression profiles are associated with molecular neurological dysfunction in the PKU mouse model

Esther Imperlini, Stefania Orrù, Claudia Corbo, Aurora Daniele, more

Journal of Neurochemistry > 129 > 6 > 1002 - 1012

Phenylketonuria (PKU), if not detected and treated in newborns, causes severe neurological dysfunction and cognitive and behavioral deficiencies. Despite the biochemical characterization of PKU, the molecular mechanisms underlying PKU‐associated brain dysfunction remain poorly understood. The aim of this study was to gain insights into the pathogenesis of this neurological damage by analyzing protein...

article

Mannose-binding lectin genetic analysis: possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men

Olga Scudiero, Maria Ludovica Monaco, Ersilia Nigro, Mario Capasso, more

International Journal of Infectious Diseases > 2014 > 19 > Complete > 100-102

Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing...

article

Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1

Ersilia Nigro, Olga Scudiero, Daniela Sarnataro, Gennaro Mazzarella, more

International Journal of Biochemistry and Cell Biology > 2013 > 45 > 6 > 1145-1153

Adiponectin (Acrp30) exerts protective functions on metabolic and cellular processes as energy metabolism, cell proliferation and differentiation by two widely expressed receptors, AdipoR1 and AdipoR2. To date, the biological role of Acrp30 in lung has not been completely assessed but altered levels of Acrp30 and modulated expression of both AdipoRs have been related to establishment and progression...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Aurora Daniele

Dietary influence on adiponectin in patients with type 2 diabetes

microRNA‐377‐3p downregulates the oncosuppressor T‐cadherin in colorectal adenocarcinoma cells

Supervised physical exercise improves clinical, anthropometric and biochemical parameters in adult cystic fibrosis patients: A 2‐year evaluation

Sports training and adaptive changes

Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells

PPARγ and ADRB3 polymorphisms analysis and Irisin expression in professional water polo players

Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance

Host defense peptide‐derived privileged scaffolds for anti‐infective drug discovery

The burden of obesity in asthma and COPD: Role of adiponectin

Evaluation of adiponectin profile in Italian patients affected by obstructive sleep apnea syndrome

Gene molecular analysis and Adiponectin expression in professional Water Polo players

Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation

Membrane Protein 4F2/CD98 Is a Cell Surface Receptor Involved in the Internalization and Trafficking of Human β-Defensin 3 in Epithelial Cells

Pituitary function and morphology in Fabry disease

Long-term follow-up of patients with phenylketonuria treated with tetrahydrobiopterin: a seven years experience

Late diagnosis of Fabry disease caused by a de novo mutation in a patient with end stage renal disease

Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma

Altered brain protein expression profiles are associated with molecular neurological dysfunction in the PKU mouse model

Mannose-binding lectin genetic analysis: possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men

Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Aurora Daniele

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options