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Electrophoretic separation of fluorescently end‐labeled DNA after a PCR serves as a gold standard in genetic diagnostics. Because of their size and cost, instruments for this type of analysis have had limited market uptake, particularly for point‐of‐care applications. This might be changed through a higher level of system integration and lower instrument costs that can be realized through the use...
In this paper we demonstrate a fully integrated 300 V low current charge pump design which has been manufactured using Teledyne DALSA's triple well 800 nm high voltage IC process. This charge pump is powered by a 5 V supply, drawing less than 2% of the USB 2.0 maximum current, thus enabling future low-cost compact point-of-care diagnostic devices that would be connected to and powered off a laptop...
Lab-on-chip technology has tremendous potential for point-of-care and in-field medical diagnostics, but the uptake of such technologies is hampered by the high cost and large size of the instrumentation conventionally required. In the present work we demonstrate an instrument that fully automates sample preparation, enzymatic digestion and electrophoresis to implement DNA sizing and restriction fragment...
Electrophoresis is an integral part of many molecular diagnostics protocols and an inexpensive implementation would greatly facilitate point-of-care (POC) applications. However, the high instrumentation cost presents a substantial barrier, much of it associated with fluorescence detection. The cost of such systems could be substantially reduced by placing the fluidic channel and photodiode directly...
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