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Presenting highly sensitive and clinically relevant functional information from soft tissues in and around the joint with spatial resolution comparable to ultrasound (US) imaging, photoacoustic (PA) imaging may shed new light on early diagnosis and treatment evaluation of human inflammatory arthritis. In this study on severe arthritis patients and healthy control subjects, we explored the potential...
Tumor acidosis, as a consequence of increased fermentative metabolism and poor perfusion, plays an important role in almost all steps of invasive growth and metastasis. Successful measurements of the extracellular pH of the tumor microenvironment can contribute to clinical management of cancer and basic science research. We herein report on an in vivo tumor pH mapping nanotechnology that includes...
Photoacoustic tomography (PAT) was used to detect the progressive changes on the cerebral cortex of Sprague–Dawley rats after the administration of cocaine hydrochloride. Different concentrations (0, 2.5, and 5.0mg per kg body) of cocaine hydrochloride in saline solution were injected into Sprague–Dawley rats through tail veins. Cerebral cortex images of the animals were continuously acquired by PAT...
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