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Interferon regulatory factor-5 (IRF5), a transcription factor critical for the induction of innate immune responses, contributes to the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE) in humans and mice. Lyn, a Src family kinase, is also implicated in human SLE, and Lyn-deficient mice develop an SLE-like disease. Here, we found that Lyn physically interacted with IRF5 to...
Monocytes are circulating blood leukocytes that regulate host defenses, inflammation and tissue homeostasis. Monocytes originate from bone marrow myeloid progenitors such as monocyte-dendritic cell progenitors (MDPs). The transcription factor Interferon Regulatory Factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet a genome-wide understanding of the differentiation program initiated...
Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and non-self molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease....
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