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The objectives here were to evaluate the effects of odanacatib (ODN) at doses exceeding the clinical exposure on biomechanical properties of lumbar vertebrae (LV), hip and central femur (CF), and compare ODN to alendronate (ALN) on bone remodeling/modeling in ovariectomized (OVX) monkeys. Ten days post-surgery, animals were treated with vehicle (VEH), ODN-L (2mg/kg/day, p.o.), ODN-H (8/4mg/kg/day),...
Antihyperglycaemic therapy on bone was evaluated in the ovariectomized (OVX), non‐diabetic adult rat. Animals were treated daily for 12 weeks with various doses of sitagliptin, pioglitazone, rosiglitazone, combinations of sitagliptin with pioglitazone or vehicle alone. Sitagliptin target engagement was confirmed by assessing inhibition of plasma dipeptidyl peptidase‐4 (DPP‐4) and oral glucose tolerance...
We demonstrate a 60-km CWDM-TDM PON with 40 Gb/s capacity both down and upstream. The system incorporates technologies such as volume manufacturable transmitters, burst-mode transmission, hybrid SOA-Raman amplifiers, and a cyclic CWDM multiplexer.
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