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Mutations in components of the Wnt signaling pathway, including β-catenin and AXIN1, are found in more than 50% of human hepatocellular carcinomas (HCCs). Disruption of Axin1 causes embryonic lethality in mice. We generated mice with conditional disruption of Axin1 to study its function specifically in adult liver. Mice with a LoxP-flanked allele of Axin1 were generated by homologous recombination...
It is extremely difficult to detect guanine nucleotide exchange or hydrolysis stimulated by receptors which couple to G s α. Furthermore, G s α is largely resistant to the GTPase-activating properties of RGS proteins. Coexpression of the vasopressin V 2 receptor with a series of chimeric G protein α subunits in which the C-terminal 6-12 amino acids of G i1 α were...
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