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Previous findings indicate that reducing brain insulin‐like growth factor I receptor (IGF‐IR) activity promotes ample neuroprotection. We now examined a possible action of IGF‐IR on brain glucose transport to explain its wide protective activity, as energy availability is crucial for healthy tissue function. Using 18FGlucose PET we found that shRNA interference of IGF‐IR in mouse somatosensory cortex...
Several decades ago, the observation that Alzheimer's disease (AD) presents early disturbances in brain glucose metabolism prompted the notion of insulin dysregulation in this condition. Since then, abundant epidemiological evidence has associated AD to insulin resistance as in type 2 diabetes mellitus (T2DM). However, because the role of insulin in brain glucose handling is not clear, it cannot yet...
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