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We examined the effects of corticotropin-releasing factor (CRF) on plasticity of optically recorded neuronal activity in the substantia gelatinosa (lamina II) of 12-18-day-old rat spinal cord slices stained with a voltage-sensitive dye. Single-pulse test stimulation to the dorsal root that activated A and C fibres evoked prolonged (>100 ms) light-absorption change in the lamina II. This response...
Effect of caffeine on C-fibre-evoked excitation in the superficial dorsal horn of rat spinal cord slices was investigated in Ca 2+ -free medium using the optical imaging technique. Perfusing slices with Ca 2+ -free solution reversibly suppressed the late phase of dorsal-root stimulus-induced excitation, leaving short-lasting optical responses that primarily represent the...
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