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DNA recombination, replication, and repair are intrinsically interconnected processes. From viruses to humans, they are ubiquitous and essential to all life on Earth. Single‐strand annealing homologous DNA recombination is a major mechanism for the repair of double‐stranded DNA breaks. An exonuclease and an annealase work in tandem, forming a complex known as a two‐component recombinase. Redβ annealase...
Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock’s archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition,...
The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2–7) into prereplicative complexes (pre-RCs). Mcm2–7 forms the core of the replicative DNA helicase, which is inactive in the pre-RC. The loading of Mcm2–7 onto DNA requires the origin recognition complex (ORC), Cdc6, and Cdt1,...
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