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Sequestration, the adherence of infected erythrocytes containing the more mature stages of parasite development (trophozoites and schizonts) to the endothelial cells lining the capillaries and post-capillary venules, is characteristic of Plasmodium falciparum infections. In this review, Irwin Sherman and his colleagues discuss recent advances in the characterization of the adhesive molecules on the...
The attachment of erythrocytes infected with Plasmodium falciparum to the microvessels of the brain leads to a pathological condition known as cerebral malaria. There are no effective therapeutic means for alleviating this. In this review, Kirkwood Land, Irwin Sherman, Jurg Gysin and Ian Crandall discuss the potential of anti-adhesive peptides and antibodies as a means of treating cerebral malaria...
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