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A voltage-sensitive K + channel previously cloned from rat heart designated RK5 (rat Kv4.2) (Roberds and Tamkun, 1991, Proc. Natl. Acad. Sci. USA 88, 1798-1802) was functionally characterized in the Xenopus oocyte expression system. RK5 is a homolog of the Drosophila Shal K + channel, activates with a rise time of 2.8 ms, has a midpoint for activation of -1 mV and rapidly inactivates...