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In previous work, we found that the protein messenger Jacob is involved in N-methyl-d-aspartate receptor (NMDAR) signaling to the nucleus and cAMP response element-binding protein (CREB) mediated gene expression in hippocampal primary neurons. Particularly, extrasynaptic NMDAR activation drives Jacob efficiently into the nucleus where it then induces gene expression that promotes neurodegeneration...
Gephyrin is the key scaffolding molecule organizing the postsynaptic density at inhibitory synapses. Utilizing localization microscopy, Specht et al. (2013) report in this issue of Neuron on the quantitative assessment of gephyrin clusters and associated glycine receptors and GABA A receptors.
The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity and cell survival signals, whereas NMDARs residing in the neuronal membrane outside synapses trigger neurodegeneration. At present, it is unclear how these opposing signals are transduced to and discriminated by the nucleus. In this study, we demonstrate that Jacob is a protein messenger that encodes the origin...
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