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Relative insolubility of inorganic Pb compounds is one of the major problems in the evaluation of the toxicological profile of this metal. Different characteristics of Pb-containing solutions may, in fact, alter the biological properties of Pb compounds and influence their toxic potency. To investigate these aspects, we used selected experimental conditions to evaluate and compare the specific biological...
In this study, the early nephrotoxic potential of mercuric chloride (HgCl 2 ) has been evaluated in vitro, by exposing a renal-derived cell system, the tubular epithelial Madin-Darby canine kidney (MDCK) cell line, to the presence of increasing HgCl 2 concentrations (0.1-100 μm) for different periods of time (from 4 to 72 h). As possible biological markers of the tubular-specific toxicity...
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