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Background: Measurement of left ventricular (LV) end-diastolic and end-systolic volumes (EDV & ESV) is important for assessment of severity, prognosis, and efficacy of interventions in dilated cardiomyopathy.Methods: We examined the accuracy of 2-dimensional (2D) echo (E) in measurement of LV EDV, ESV and ejection fraction (EF) in 11 pts with dilated LV and systolic dysfunction (EF 37 +/- 8%....
The mechanisms responsible for sustained clinical benefits after a 72 hour infusion of dobutamine (D) are unclear. We hypothesize that by increasing peripheral blood flow for 72 hours D may exert a prolonged effect on vascular endothelial function. Accordingly, HR, brachial artery (BA) diameter (d) and velocity-time integral were measured by Doppler echocardiography in 13 patients with severe CHF...
Recombinant human B-type natriuretic peptide (rhBNP), produced using a fusion protein in Escherichia coli, is identical to endogenous hBNP but has not been previously studied in humans. In a randomized, placebo-controlled, multicenter, double-blind study, effects of a continuous infusion of 2 doses of rhBNP on symptoms and hemodynamics were assessed in 127 patients with acutely decompensated congestive...