Search results for: Ming-Kuan Hu

Items from 1 to 20 out of 21 results

article

A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel

Kuo‐Feng Huang, Kuo‐Hsing Ma, Yu‐Chien Hung, Liang‐Chuan Lo, more

Journal of Cellular Physiology > 233 > 12 > 9594 - 9610

Copper is more likely than iron to generate reactive oxygen species (ROS) in a redox reaction due to its higher electrochemical reactivity. This study examined the effect of a newly synthesized Cu²⁺ binding compound, (E)‐2‐(4‐(dimethylamino)phenylimino)methyl)quinolin‐8‐ol (DPMQ), on ultraviolet B (UVB) irradiation–induced cytotoxicity in human dermal fibroblasts. DPMQ induced Cu²⁺ influx as effectively...

article

Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus

Jeng-Wei Lu, Po-Shiuan Hsieh, Chang-Chi Lin, Ming-Kuan Hu, more

Biochemical and Biophysical Research Communications > 2017 > 491 > 3 > 595-602

Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (−)-Epigallocatechin-3-gallate (EGCG) and the underlying mechanisms. Specifically, we used U2OS cells infected...

article

Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

Hue‐Yu Wang, Ming‐Kung Yeh, Chung‐Han Ho, Ming‐Kuan Hu, more

Pharmacoepidemiology and Drug Safety > 26 > 1 > 71 - 80

Purpose To analyze and characterize data regarding the prevalence and types of outpatient drug‐related problems (DRPs) found by clinical pharmacists after implementation of the Virtual Medicine Record in Cloud System (VMRCS). Methods A cross‐sectional study regarding outpatient pharmaceutical care was conducted at a medical center in Taiwan. Patients aged >20 years old with multiple chronic...

article

New Hydroxyquinoline‐Based Derivatives as Potent Modulators of Amyloid‐β Aggregations

Chin‐Lan Fu, Li‐Shin Hsu, Yung‐Feng Liao, Ming‐Kuan Hu

Archiv der Pharmazie > 349 > 5 > 327 - 341

Copper and zinc have been found to contribute to the burden of amyloid‐β (Aβ) aggregations in neurodegenerative Alzheimer's disease (AD). Dysregulation of these metals leads to the generation of reactive oxygen species (ROS) and eventually results in oxidative damage and accumulation of the Aβ peptide, which are the key elements of the disease. Aiming to pursue the discovery of new modulators for...

article

Improved and optimized one-pot method for N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) synthesis using microwaves

Kang-Po Li, Ming-Kuan Hu, Clifton Kwang-Fu Shen, Wei-Yu Lin, more

Applied Radiation and Isotopes > 2014 > 94 > C > 113-117

N-Succinimidyl-4-[¹⁸F]fluorobenzoate ([¹⁸F]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [¹⁸F]SFB with high efficacy. Herein, we reveal an improved and optimized approach based on this former model for producing [¹⁸F]SFB. With optimized approaches, the entire protocol can be...

article

Discovery of small molecular (d)-leucinamides as potent, Notch-sparing γ-secretase modulators

Yung-Feng Liao, Yu-Cheng Tang, Ming-Yun Chang, Bo-Jeng Wang, more

European Journal of Medicinal Chemistry > 2014 > 79 > Complete > 143-151

Structural optimization of the prior lead 3 led to the small molecular (d)-leucinamides with potent modulating activity and Notch-sparing selectivity on the proteolytic processing of amyloid-β precursor proteins. The N-(R)-epoxypropyl analog 10c exhibited potent γ-secretase modulation compared to DAPT and showed substantial substrate selection for APP cleavage over Notch cleavage, while N-(2-fluoro)benzyl...

article

Efficacy of simethicone and N‐acetylcysteine as premedication in improving visibility during upper endoscopy

Wei‐Kuo Chang, Ming‐Kung Yeh, Hsuang‐Chun Hsu, Hsuan‐Wei Chen, more

Journal of Gastroenterology and Hepatology > 29 > 4 > 769 - 774

BackgroundSimethicone and N‐acetylcysteine have been widely used in improving endoscopic visibility. However, the optimal dose, volume, and dosing time for the premedication regimen are still unclear. AimOur aim was to assess the efficacy of premedication in improving endoscopic visibility and determine the contributions of dose, volume, and premedication time. MethodsA total of 1849 patients were...

article

Difluorophenylglycinols as New Modulators of Proteolytic Processing of Amyloid Precursor Proteins

Chia‐Yu Chen, Yung‐Feng Liao, Ming‐Yun Chang, Ming‐Kuan Hu

Archiv der Pharmazie > 347 > 3 > 161 - 173

Synthesis and evaluation of difluorophenylglycinols as new modulators of proteolytic processing of the amyloid‐β precursor proteins for Alzheimer's therapies were described. A range of N‐substituted (R)‐ and (S)‐difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N‐substituents. Evans' chiral auxiliary strategy was...

article

Ligand-Dependent Activation of EphA4 Signaling Regulates the Proteolysis of Amyloid Precursor Protein Through a Lyn-Mediated Pathway

Wei-Bin Lai, Bo-Jeng Wang, Ming-Kuan Hu, Wen-Ming Hsu, more

Molecular Neurobiology > 2014 > 49 > 2 > 1055-1068

Alzheimer's disease is the most common dementia afflicting the elderly in modern society. This disease arises from the neurotoxicity elicited by abnormal aggregates of amyloid-β (Aβ) protein. Such aggregates form through the cleavage of amyloid precursor protein (APP) by β-secretase and the subsequent proteolysis of the APP C-terminal fragment (APP-βCTF or C99) by γ-secretase to yield Aβ and APP intracellular...

article

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

Ying-Tsen Tung, Bo-Jeng Wang, Wen-Ming Hsu, Ming-Kuan Hu, more

Molecular Neurobiology > 2014 > 49 > 1 > 10-27

Mutations in presenilin-1 (PS1) are tightly associated with early-onset familial Alzheimer’s disease (FAD), which is characterized by extracellular amyloid plaques and the accumulation of intracellular Tau. In addition to being the catalytic subunit of γ-secretase, PS1 has been shown to regulate diverse cellular functions independent of its proteolytic activity. We found that cells deficient in PS1...

article

Preparation and characterization of functional fabrics from bamboo charcoal/silver and titanium dioxide/silver composite powders and evaluation of their antibacterial efficacy

Fu-Chu Yang, Kuo-Hui Wu, Jen-Wei Huang, Deng-Nan Horng, more

Materials Science & Engineering C > 2012 > 32 > 5 > 1062-1067

Bamboo charcoal supporting silver (BC/Ag) and titanium dioxide supporting silver (TiO ₂ /Ag) were prepared by activation and chemical reduction. The BC/Ag and TiO ₂ /Ag composites were characterized by silver particle size and distribution and antibacterial properties. The pore and surface properties were studied in terms of BET volumetric measurement with nitrogen adsorption, X-ray...

article

Autophagy: A double-edged sword in Alzheimer’s disease

Ying-Tsen Tung, Bo-Jeng Wang, Ming-Kuan Hu, Wen-Ming Hsu, more

Journal of Biosciences > 2012 > 37 > 1 > 157-165

Autophagy is a major protein degradation pathway that is essential for stress-induced and constitutive protein turnover. Accumulated evidence has demonstrated that amyloid-β (Aβ) protein can be generated in autophagic vacuoles, promoting its extracellular deposition in neuritic plaques as the pathological hallmark of Alzheimer’s disease (AD). The molecular machinery for Aβ generation, including APP,...

article

Preparation and antibacterial efficacy of bamboo charcoal/polyoxometalate biological protective material

Fu-Chu Yang, Kuo-Hui Wu, Wen-Po Lin, Ming-Kuan Hu

Microporous and Mesoporous Materials > 2009 > 118 > 1-3 > 467-472

Nanocomposites based on Keggin-type polyoxometalate H ₅ PV ₂ Mo ₁₀ O ₄₀ (POM) and porous bamboo charcoal (BC) were prepared by activation and immobilization processes. The physical properties of the BC/POM composites were examined using FTIR, UV–Vis spectroscope, ³¹ P MAS-NMR, SEM and TEM. These techniques indicated that the POM was intact on the surface of...

article

Evaluation of the antibacterial efficacy of bamboo charcoal/silver biological protective material

Fu-Chu Yang, Kuo-Hui Wu, Ming-Jie Liu, Wen-Po Lin, more

Materials Chemistry and Physics > 2009 > 113 > 1 > 474-479

Bamboo charcoal supporting silver (BC/Ag) was prepared by activation and chemical reduction. The BC/Ag composites were characterized by silver particle size and distribution, silver ion (Ag ⁺ ) release and antibacterial properties. Scanning and transmission electron microscopy (SEM and TEM) showed that the Ag particles were distributed uniformly on the BC matrix. The Ag particle size was found...

article

Sodium selenite inhibits γ-secretase activity through activation of ERK

Ying-Tsen Tung, Wen-Ming Hsu, Bo-Jeng Wang, Shin-Ying Wu, more

Neuroscience Letters > 2008 > 440 > 1 > 38-43

Previous studies have demonstrated that the ERK MAPK acts as a negative regulator of γ-secretase. Here, we demonstrate that the activation of ERK MAPK pathway by sodium selenite can inhibit endogenous γ-secretase activity. Consistently, the γ-secretase-mediated production of amyloid-β (Aβ) was dramatically attenuated by sodium selenite in a temporal manner. To substantiate the functional role of ERK...

article

New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins

Ming-Kuan Hu, Yung-Feng Liao, Jung-Fang Chen, Bo-Jeng Wang, more

Bioorganic & Medicinal Chemistry > 2008 > 16 > 4 > 1957-1965

A type of new 1,2,3,4-tetrahydroisoquinoline derivatives was synthesized via concise procedure from commercially available tetrahydroisoquinoline. These derivatives were delicately designed to possess propargyl-related pharmacophores simulated with a monoamine oxidase inhibitor rasagiline. We investigated the effect of these synthetic tetrahydroisoquinoline derivatives on the regulation of proteolytic...

article

Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase with enhanced stability

Yung-Feng Liao, Bo-Jeng Wang, Chia-Yin Liao, Shin-Ying Wu, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2006 > 2 > 3 Supplement > S448-S449

article

Allylmagnolol, a novel magnolol derivative as potent antioxidant

Chi-Yuan Li, Yvonne Wang, Ming-Kuan Hu

Bioorganic & Medicinal Chemistry > 2003 > 11 > 17 > 3665-3671

We reported the discovery of potent antioxidants based on magnolol, a naturally occurring biphenolic obtained from the bark of Magnolia officinalis. The allylmagnolols 3a,b were synthesized via O-alkylation of the biphenols followed by Claisen rearrangement. In-vitro using enhanced chemiluminescence (CL) and flow cytometric assays in whole cells revealed that both 3a and 3b displayed promising free...

article

Homodimeric Tacrine Congeners as Acetylcholinesterase Inhibitors ^†

Ming-Kuan Hu, Li-Ju Wu, George Hsiao, Mao-Hsiung Yen

Journal of Medicinal Chemistry > 2002 > 45 > 11 > 2277 - 2282

article

A facile synthesis of bis-tacrine isosteres

Ming-Kuan Hu, Chih-Feng Lu

Tetrahedron Letters > 2000 > 41 > 11 > 1815-1818

An efficient synthesis of highly potent and selective acetylcholinesterase (AChE) inhibitors, bis-tacrines and their isosteres 2-4, has been accomplished by bis-amination of 9-chloro-tetrahydroacridine (9a) and its analogs. The critical intermediates were concisely prepared in situ by heating the corresponding ortho-amino aromatic acids and cycloketones in the presence of phosphorus oxychloride.

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Search results for: Ming-Kuan Hu

A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel

Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus

Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

New Hydroxyquinoline‐Based Derivatives as Potent Modulators of Amyloid‐β Aggregations

Improved and optimized one-pot method for N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) synthesis using microwaves

Discovery of small molecular (d)-leucinamides as potent, Notch-sparing γ-secretase modulators

Efficacy of simethicone and N‐acetylcysteine as premedication in improving visibility during upper endoscopy

Difluorophenylglycinols as New Modulators of Proteolytic Processing of Amyloid Precursor Proteins

Ligand-Dependent Activation of EphA4 Signaling Regulates the Proteolysis of Amyloid Precursor Protein Through a Lyn-Mediated Pathway

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

Preparation and characterization of functional fabrics from bamboo charcoal/silver and titanium dioxide/silver composite powders and evaluation of their antibacterial efficacy

Autophagy: A double-edged sword in Alzheimer’s disease

Preparation and antibacterial efficacy of bamboo charcoal/polyoxometalate biological protective material

Evaluation of the antibacterial efficacy of bamboo charcoal/silver biological protective material

Sodium selenite inhibits γ-secretase activity through activation of ERK

New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins

Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase with enhanced stability

Allylmagnolol, a novel magnolol derivative as potent antioxidant

Homodimeric Tacrine Congeners as Acetylcholinesterase Inhibitors ^†

A facile synthesis of bis-tacrine isosteres

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