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The activity-dependent modifications in neural circuits that underlie all forms of experience-dependent plasticity are thought to involve long-lasting changes in the strength of synaptic transmission at excitatory synapses. The most well characterized forms of such synaptic plasticity, termed long-term potentiation (LTP) and long-term depression (LTD), have been implicated in playing important roles...
Drug seeking and drug self-administration in both animals and humans can be triggered by drugs of abuse themselves or by stressful events. Here, we demonstrate that in vivo administration of drugs of abuse with different molecular mechanisms of action as well as acute stress both increase strength at excitatory synapses on midbrain dopamine neurons. Psychoactive drugs with minimal abuse potential...
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