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Dictyostelium morphogenesis requires the tip, which acts as an organizer and conducts orchestrated cell movement and cell differentiation. At the slug stage the tip region contains prestalk A (pstA) cells, which are usually recognized by their expression of reporter constructs that utilize a fragment of the promoter of the ecmA gene. Here, using the promoter region of the o-methyl transferase 12 gene...
In this issue of Developmental Cell, Pan et al. (2016) identified in cells of the social amoeba Dictyostelium a G protein-coupled receptor (GPCR) that recognizes a chemoattractant secreted by bacteria. This work uncovers a mechanism by which a single GPCR mediates pseudopod extension during cell migration and bacterial engulfment.
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