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Facial wrinkles are caused by weakening of the sub-dermal collagen support layer. Dermal fillers can be used to treat wrinkles, and this double-blind, randomised, single-centre study compared four fillers: PRI 1, PRI 2 (both porcine collagen), Zyplast ® (purified bovine collagen) and Perlane ® (cross-linked hyaluronic acid gel).79 females (aged 25–55 years) with wrinkles in the upper...
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