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The optimum drug treatment for ultrarefractory epilepsy after failure of seven prior antiepileptic drugs (AEDs) remains uncertain. Prompted by reports that adjunctive amantadine or l-dopa has been useful for children with refractory absence seizures and Lennox–Gastaut syndrome, we studied the utility of dopaminergic agents for adults with ultrarefractory epilepsy.We assessed seizure control following...
Sleepwalking in adolescents and adults may lead to serious injuries and require treatment. Anecdotal treatment recommendations include benzodiazepines (which also work in focal seizures of the frontal lobe that are an important differential diagnosis), imipramine and amitriptyline.We assessed in a follow-up study of 4years (medium, range: 2–7years) the usefulness of the antiparkinsonian drug biperiden...
Purpose: To evaluate the long‐term efficacy and safety of once daily eslicarbazepine acetate (ESL) as adjunctive therapy for partial‐onset seizures in adults with epilepsy.
Methods: One‐year open‐label treatment extension with ESL in patients who completed a placebo‐controlled pivotal study (Epilepsia 2009; 50: 454–463). Starting dose was 800 mg once daily, for 4 weeks; thereafter, dose could be...
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