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The UK civil space strategy for the years 2008–2012 and beyond was published in February 2008. This paper describes the key features of the strategy and highlights those areas that are new or different from the aims set out in previous strategies. In particular, the strategy lays out a new five-part high-level vision for UK civil space.
dTDP-D-glucose 4,6-dehydratase (RmlB) was first identified in the L-rhamnose biosynthetic pathway, where it catalyzes the conversion of dTDP-D-glucose into dTDP-4-keto-6-deoxy-D-glucose. The structures of RmlB from Salmonella enterica serovar Typhimurium in complex with substrate deoxythymidine 5'-diphospho-D-glucose (dTDP-D-glucose) and deoxythymidine 5'-diphosphate (dTDP), and RmlB from Streptococcus...
Flavonoids are common colorants in plants and have long-established biomedicinal properties. Anthocyanidin synthase (ANS), a 2-oxoglutarate iron-dependent oxygenase, catalyzes the penultimate step in the biosynthesis of the anthocyanin class of flavonoids. The crystal structure of ANS reveals a multicomponent active site containing metal, cosubstrate, and two molecules of a substrate analog (dihydroquercetin)...
Ester derivatives of clavulanic acid acylate Ser-195 of the serine protease porcine pancreatic elastase to form stable malonyl semi-aldehyde derivatives, analogous to those formed in the inhibition of β-lactamases by clavulanic acid itself. Formation of such derivatives maybe a general way of inhibiting 'serine' enzymes.
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