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Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and anti-allodynia effects in both preclinical and clinical studies. In the present study, we investigated the role of systemic administration of melatonin on oxaliplatin-induced pain. Intraperitoneal (i.p.) injection with oxaliplatin...
The purpose of the study was to evaluate the value of heart-type fatty acid–binding protein (hFABP) as a novel clinical biomarker in patients with severe sepsis.Serum concentrations of hFABP and traditional cardiac biomarkers including cardiac troponin I, creatine kinase–MB, and B-type natriuretic peptides levels were measured within 6 hours after admission in 93 severe septic patients. The value...
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