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Plasma homocysteine has been shown in vivo to cause endothelial damage. The hyperemic brachial artery response to ischemia is a noninvasive test to evaluate endothelial function. Patients with CAD have been shown to have abnormal endothelial function as measured by hyperemic brachial artery response. We hypothesized that homocysteine may contribute to endothelial dysfunction in patients with CAD...