Search results for: Ellen De Langhe

Items from 1 to 20 out of 20 results

article

Association of Combined Anti‐Ro52/TRIM21 and Anti‐Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation

Eléonore Bettacchioli, Alain Saraux, Alice Tison, Divi Cornec, more

Arthritis & Rheumatology > 76 > 5 > 751 - 762

Objective The biologic diagnosis of primary Sjögren disease (SjD) mainly relies on anti‐Ro60/SSA antibodies, whereas the significance of anti‐Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti‐Ro52/TRIM21 antibody status. Methods Patients...

article

The hallux patch: A new cutaneous sign of anti‐MDA5‐positive dermatomyositis?

Jean‐Baptiste Vulsteke, Ellen De Langhe, Petra De Haes

Journal of the European Academy of Dermatology and Venereology > 37 > 8 > e1046 - e1048

article

Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology

Martin Kerick, David González‐Serna, Elena Carnero‐Montoro, Maria Teruel, more

Arthritis & Rheumatology > 73 > 7 > 1288 - 1300

Objective To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQTLs]) in systemic sclerosis (SSc) and to investigate their role in the pathogenesis of the disease. Methods We performed an eQTL analysis using whole‐blood sequencing data from 333 SSc patients and 524 controls and integrated them with SSc genome‐wide association study (GWAS) data. We integrated...

article

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Guillermo Barturen, Sepideh Babaei, Francesc Català‐Moll, Manuel Martínez‐Bueno, more

Arthritis & Rheumatology > 73 > 6 > 1073 - 1085

Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was undertaken to identify molecular clusters for reclassifying systemic autoimmune diseases independently of clinical diagnosis. Methods Unsupervised clustering...

article

Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology

Emily‐Ann Butler, Murray Baron, Agnes B. Fogo, Tracy Frech, more

Arthritis & Rheumatology > 71 > 6 > 964 - 971

Objective To generate a core set of items to develop classification criteria for scleroderma renal crisis (SRC) using consensus methodology. Methods An international, multidisciplinary panel of experts was invited to participate in a 3‐round Delphi exercise developed using a survey based on items identified by a scoping review. In round 1, participants were asked to identify omissions and clarify...

article

Physical therapy in adult inflammatory myopathy patients: a systematic review

Anna Van Thillo, Jean-Baptiste Vulsteke, Dieter Van Assche, Patrick Verschueren, more

Clinical Rheumatology > 2019 > 38 > 8 > 2039-2051

The safety and effect of physical therapy in adult patients with idiopathic inflammatory myopathies (IIMs) are currently unclear. Considering the muscle weakness resulting from disease activity as well as from the administered drugs, these patients could benefit from an evidence-based physical therapy program. To perform a systematic review to assess safety and effects of physical therapy on the functional...

article

Treatment adherence in systemic sclerosis: A cross‐sectional study

Jan Brijs, Seher Arat, Rene Westhovens, Jan Leo Lenaerts, more

Musculoskeletal Care > 17 > 1 > 44 - 53

Background Treatment adherence is an important medical and pharmaco‐economical phenomenon, influenced by multiple variables. Treatment adherence in systemic sclerosis (SSc) has been poorly studied. Objective The aim of the present study was to assess treatment adherence in SSc patients and to identify factors associated with good and poor adherence. Methods We conducted a monocentric, cross‐sectional,...

article

Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study

Veronika K. Jaeger, Gabriele Valentini, Eric Hachulla, Franco Cozzi, more

Arthritis & Rheumatology > 70 > 11 > 1829 - 1834

Objective Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. Methods Adult SSc patients with data on smoking history and a 12–24‐month follow‐up visit were included....

article

Diagnostic Ability of a Dynamic Multidisciplinary Discussion in Interstitial Lung Diseases

Laurens J. De Sadeleer, Caressa Meert, Jonas Yserbyt, Hans Slabbynck, more

Chest > 2018 > 153 > 6 > 1416-1423

The advice of a dynamic multidisciplinary discussion (MDD) is believed to be important in the diagnosis of interstitial lung diseases (ILDs). However, to what extent MDD diagnoses differ from the preliminary diagnoses before formal workup and MDD (preMDD diagnoses) is still insufficiently studied.We compared preMDD and MDD diagnoses in patients discussed at the Leuven University Hospitals MDDs between...

article

High prevalence of occupational exposure to solvents or silica in male systemic sclerosis patients: a Belgian cohort analysis

Evelien De Decker, Marie Vanthuyne, Daniel Blockmans, Frederic Houssiau, more

Clinical Rheumatology > 2018 > 37 > 7 > 1977-1982

Increasing evidence supports a relation of some occupational exposures to systemic sclerosis pathogenesis. We aimed to evaluate occupational exposure and clinical characteristics in male patients with systemic sclerosis followed in two Belgian academic hospitals. One hundred and three male patients, included in the Belgian Systemic Sclerosis Cohort, were identified. An expert in occupational medicine...

article

Proceedings of the 23^rd Paediatric Rheumatology European Society Congress: part three

Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, more

Pediatric Rheumatology > 2017 > 15 > 1 > 203-259

article

Development and preliminary evaluation of the validity and reliability of a revised illness perception questionnaire for healthcare professionals

Seher Arat, Anke Van den Zegel, Maity Van Rillaer, Philip Moons, more

BMC Nursing > 2016 > 15 > 1 > 1-9

Background Diverging perceptions between individual patients with somatic diseases and their healthcare professionals might cause problems in communication and decision-making. To date, no measurement tool is available to compare the illness perceptions between these two groups. The Revised Illness Perception Questionnaire (IPQ-R) is a validated, widely used instrument in many patient populations...

article

Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis

Ellen De Langhe, Frederic Cailotto, Vanessa De Vooght, Carolina Aznar-Lopez, more

Respiratory Research > 2015 > 16 > 1 > 1-10

Background Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ superfamily of growth factors, modulate fibrogenesis driven by TGFβ. We therefore studied the role of endogenous...

article

Fibrogenesis, novel lessons from animal models

Ellen De Langhe, Rik Lories

Seminars in Immunopathology > 2015 > 37 > 5 > 565-574

Systemic sclerosis (SSc) is a devastating chronic autoimmune connective tissue disease characterized by vasculopathy, autoimmunity with inflammation, and progressive fibrogenesis. The current paradigm of the pathogenesis of SSc is that of an unknown initial trigger, leading to a complex interaction of immune cells, endothelial cells, and fibroblasts, producing cytokines, growth and angiogenic factors,...

article

Mechanic’s hands in a woman with undifferentiated connective tissue disease and interstitial lung disease – anti-PL7 positive antisynthetase syndrome: a case report

Ellen De Langhe, Jan Lenaerts, Xavier Bossuyt, Rene Westhovens, more

Journal of Medical Case Reports > 2015 > 9 > 1 > 1-5

Introduction Interstitial lung disease can be idiopathic or occur in the setting of connective tissue diseases. In the latter case it requires a different treatment approach with a better prognosis. Interstitial lung disease can precede the onset of typical connective tissue disease features by many years, and therefore meticulous multidisciplinary follow-up is crucial. This case highlights the...

article

Pulmonary inflammation in mice with collagen‐induced arthritis is conditioned by complete Freund's adjuvant and regulated by endogenous IFN‐γ

Evelien Schurgers, Freya Mertens, Jeroen A. J. Vanoirbeek, Stéphanie Put, more

European Journal of Immunology > 42 > 12 > 3223 - 3234

Following immunization with collagen II (CII) in complete Freund's adjuvant (CFA), DBA/1 mice develop arthritis of major joints. This collagen‐induced arthritis (CIA) is used as a model for rheumatoid arthritis (RA) in man. Inflammatory changes in lung tissue commonly occur in RA. However, evidence for pulmonary inflammation in CIA is scarce and ambiguous. Here, we demonstrate pulmonary inflammation...

article

The Association of Illness Perceptions with Physical and Mental Health in Systemic Sclerosis Patients: An Exploratory Study

Seher Arat, Patrick Verschueren, Ellen De Langhe, Vanessa Smith, more

Musculoskeletal Care > 10 > 1 > 18 - 28

ObjectiveThe aim of the present study was to evaluate the association between illness perceptions and the ability to cope with physical and mental health problems in a large cohort of systemic sclerosis (SSc) patients. MethodsThis was a cross‐sectional study in 217 systemic sclerosis patients from the Belgian Systemic Sclerosis Cohort. Illness perception and coping were measured by the Revised Illness...

article

The kaleidoscopic presentation of the spondyloarthritis concept in a female patient

Ellen De Langhe, Rik Lories, Kristin Maenaut, Kurt De Vlam

Joint Bone Spine > 2011 > 78 > 6 > 638-640

Spondyloarthritis is a group of chronic joint diseases that share clinical, pathological and genetic features and is divided into distinct diagnostic entities, including ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease-associated spondyloarthritis, reactive arthritis, juvenile onset and undifferentiated spondyloarthritis. Since the spectrum of spondyloarthritides is wider than...

article

Tableau clinique kaléidoscopique illustrant le concept de spondylarthropathie chez une femme

Ellen De Langhe, Rik Lories, Kristin Maenaut, Kurt De Vlam

Revue du rhumatisme > 2011 > 78 > 6 > 574-577

Les spondylarthropathies sont une famille d’arthropathies chroniques qui partagent diverses caractéristiques cliniques, histologiques et génétiques. Cette famille comprend plusieurs entités cliniques, comme la spondylarthrite ankylosante, le rhumatisme psoriasique, les spondylarthropathies des entérocolopathies inflammatoires chroniques, les arthrites réactionnelles, les spondylarthropathies juvéniles...

article

Hand Radiological Damage in Systemic Sclerosis: Comparison with a Control Group and Clinical and Functional Correlations

Sophie Koutaissoff, Marie Vanthuyne, Vanessa Smith, Ellen De Langhe, more

Seminars in Arthritis and Rheumatism > 2011 > 40 > 5 > 455-460

To define the burden of hand radiological damage in systemic sclerosis (SSc) patients, compared with a control group.Both hands of 167 SSc patients and 168 hands (82 right and 86 left) of age- and gender-matched controls were imaged by conventional radiograph. Two musculoskeletal radiologists semiquantitatively scored the following lesions: tuft acro-osteolysis, tuft calcinosis, joint space narrowings,...

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Search results for: Ellen De Langhe

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