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The classical roles of α 2 δ proteins are as accessory calcium channel subunits, enhancing channel trafficking. They were thought to have type-I transmembrane topology, but we find that they can form GPI-anchored proteins. Moreover α 2 δ-1 and α 2 δ-3 have been shown to have novel functions in synaptogenesis, independent of their effect on calcium channels. In neurons, the...
Acid-sensing ion channels are excitatory receptors for extracellular H + . Since the extracellular H + concentration can significantly increase during an inflammation, one of the proposed functions for ASICs is peripheral perception of pain. The ASIC1b and ASIC3 subunits are specifically expressed in sensory ganglia neurons and are candidate sensors of peripheral acidosis. However,...
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