Search results for: Vijaykumar Deore

Items from 1 to 4 out of 4 results

article

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Venkatasubbaiah A Venkatesha, Asavari Joshi, Magesh Venkataraman, Vinay Sonawane, more

Molecular Cancer > 2014 > 13 > 1 > 1-11

Background Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PIK3CA, BRAF, and others that drive tumor growth. Some patients though initially respond, but later develop resistance to erlotinib/gefitinib with no option except for cytotoxic therapy. Therefore,...

article

Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

Nilambari Yewalkar, Vijaykumar Deore, Amol Padgaonkar, Sonal Manohar, more

Bioorganic & Medicinal Chemistry Letters > 2010 > 20 > 22 > 6426-6429

Hypoxia-inducible factor-1α (HIF-1α) is a critical regulatory protein of cellular response to hypoxia, and regulates the transcription of many genes involved in key aspects of cancer biology, including immortalization, maintenance of stem cell pools, cellular dedifferentiation, vascularization, and invasion/metastasis. HIF-1α has been implicated in the regulation of genes involved in angiogenesis,...

article

Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors

Vijaykumar Deore, Nilambari Yewalkar, Dimple Bhatia, Nikesh Desai, more

Bioorganic & Medicinal Chemistry Letters > 2009 > 19 > 11 > 2949-2952

A series of novel cyanopyridyl based molecules (1–14) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-linked immunoassays and Western blot analysis. Most importantly, systemic application (intraperitoneal; ip) of compound 14 significantly suppressed macroscopic...

article

Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

Manoj V. Lohar, Ramswaroop Mundada, Mandar Bhonde, Amol Padgaonkar, more

Bioorganic & Medicinal Chemistry Letters > 2008 > 18 > 12 > 3603-3606

We herein report the design and synthesis of furoquinoline based novel molecules (16–36) and their in vitro multiple targeted inhibitory potency against PI3K/Akt phosphorylation and mTOR using cell based and cell-free kinase assay. In particular, compound 23 in addition to PI3K-mTOR inhibitory potency, it has shown potent inhibition of hypoxia-induced accumulation of HIF-1α protein in U251-HRE cell...

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Search results for: Vijaykumar Deore

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors

Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

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INFONA - science communication portal

Search results for: Vijaykumar Deore

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors

Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

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