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The brain-specific 42-kDa protein, p42IP4, contains a N-terminal zinc finger (ZF) motif and a tandem of two pleckstrin homology (PH) domains. p42IP4 binds in vitro the second messengers phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P3) and inositol(1,3,4,5)tetrakisphosphate (Ins(1,3,4,5)P4). We observed by confocal microscopy in live HEK 293 cells the GFP-p42IP4, a chimera of human p42IP4...
In this study we describe for the human inositol-(1,3,4,5)-tetrakisphosphate (InsP 4 )-binding protein, p42 IP4 , the cellular distribution and subcellular localization in human brain and in transfected neuronal cells. The cDNA sequence of the human p42 IP4 containing a single open reading frame yields a peptide of 374 amino acids with a calculated molecular...
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