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Four hundred novel human leukocyte antigen (HLA) alleles were identified in Chinese individuals: 100 HLA‐A alleles, 100 HLA‐B alleles, 101 HLA‐C alleles, 28 HLA‐DRB1 alleles and 71 HLA‐DQB1 alleles. Comparing novel alleles with their most homologous allele, we found 72.73% non‐synonymous nucleotide substitutions, 21.13% silent mutations, 3.90% nonsense mutations and 3.25% frameshift mutation. 352...
A novel human leukocyte antigen (HLA)‐DRB1 allele, DRB1*08:36, has been identified during routine sequence‐specific oligonucleotide (SSO) typing and sequence‐based typing (SBT) in a sample from a registered donor of Chinese Marrow Donor Program. The DRB1*08:36 allele differs from the closest related DRB1*08:03:02 allele by one nucleotide substitution in exon 2, at position 181 which results in an...
A novel human leukocyte antigen‐A allele, officially named HLA‐A*0131N allele, was found in a potential Chinese bone marrow donor when direct sequence‐based typing was carried out. The novel A*0131N is identical to A*01010101 with an exception of one base substitution at position 178 (G>A) of exon 2 resulting in codon #60 changed from TGG (Trp) to TAG (stop codon).
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