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A rabbit model was used for the evaluation of a collagen-based biomatrix of small intestinal submucosa (SIS, COOK ( R)) in comparison to a biochemically reconstructed biomatrix for bladder tissue regeneration. Rabbits underwent partial cystectomy and cystoplasty with SIS patch graft or with a biochemically defined collagen biomatrix. The grafts of the regenerated bladder wall were harvested...
Objective: The evaluation of collagen-based biomatrix (SIS COOK ( R)) in comparison to a biochemically reconstructed biomatrix for replacement of the urethra in a rabbit model as a preclinical model.Material and Methods: Rabbits underwent partial urethra replacement (resection of 0.5 to 1.0cm segment of the urethra), which was replaced with 1 or 4 layers Small Intestinal Submucosa (SIS COOK...
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