James H. Park

article

The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy

Fiona A. Ross, James H. Park, David Mansouri, Cariss Little, more

Aim Although the relationship between colorectal neoplasia and inflammation is well described, the role of faecal calprotectin (FC) in clinical practice to diagnose or screen patients for colorectal neoplasia is less defined. This prospective study characterizes the relationship between FC and colorectal neoplasia in patients within the faecal occult blood testing (FOBT) positive patients in the...

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The Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer

Hester C. Wyk, Antonia Roseweir, Peter Alexander, James H. Park, more

Annals of Surgical Oncology > 2019 > 26 > 13 > 4397-4404

Background Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well-defined by the International Tumour Budding Consensus Conference (ITBCC). Objective The aim of the present study was to use the ITBCC budding evaluation method to examine the relationship between tumor budding, tumor factors, tumor microenvironment, and survival in patients with primary...

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The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer

Antonia K. Roseweir, Jennifer Clark, Stephen T. McSorley, Hester C. vanWyk, more

International Journal of Cancer > 144 > 9 > 2320 - 2329

Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. A cohort of 150 patients with stage I‐III CRC were utilised to assess tumour cell expression...

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Loss of N‐WASP drives early progression in an Apc model of intestinal tumourigenesis

Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, more

The Journal of Pathology > 245 > 3 > 337 - 348

N‐WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N‐WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal...

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Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer

David G. Watt, Michelle L. Ramanathan, Stephen T. McSorley, Killian Walley, more

Annals of Surgical Oncology > 2017 > 24 > 9 > 2588-2594

Introduction The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory...

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In reply to ‘Hynes et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population‐based study’

James H Park, Campbell S D Roxburgh, Joanne Edwards, Paul G Horgan, more

Histopathology > 71 > 2 > 326 - 327

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A Postoperative Systemic Inflammation Score Predicts Short- and Long-Term Outcomes in Patients Undergoing Surgery for Colorectal Cancer

David G. Watt, Stephen T. McSorley, James H. Park, Paul G. Horgan, more

Annals of Surgical Oncology > 2017 > 24 > 4 > 1100-1109

Background Following surgery, a significant proportion of patients develop postoperative complications that are associated with poorer long-term survival. Stereotypical markers of the systemic inflammatory response (SIR) have been shown to identify patients at increased risk of developing such complications. The aim of the present study was to examine the prognostic value of a postoperative systemic...

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Long-Term Follow-Up of Patients Undergoing Resection of TNM Stage I Colorectal Cancer: An Analysis of Tumour and Host Determinants of Outcome

David Mansouri, Arfon G. Powell, James H. Park, Donald C. McMillan, more

World Journal of Surgery > 2016 > 40 > 6 > 1485-1491

Background Screening for colorectal cancer improves cancer-specific survival (CSS) through the detection of early-stage disease; however, its impact on overall survival (OS) is unclear. The present study examined tumour and host determinants of outcome in TNM Stage I disease. Methods All patients with pathologically confirmed TNM Stage I disease across 4 hospitals in the North of Glasgow between...

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Neutrophil count is the most important prognostic component of the differential white cell count in patients undergoing elective surgery for colorectal cancer

David G. Watt, John C. Martin, James H. Park, Paul G. Horgan, more

The American Journal of Surgery > 2015 > 210 > 1 > 24-30

Systemic inflammatory scoring systems such as the NLR have been reported to have prognostic value in many solid organ cancers. The aim of this study was to examine the relationships between the components of the white cell count (WCC) and survival in patients undergoing elective surgery for colorectal cancer.Patients undergoing elective resection at a single center (1997 to 2008) were identified from...

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879 The Validation of C-Reactive Protein and Albumin As Predictors of Post-Operative Infective Complications and Their Clinical Utility in Patients With Colorectal Cancer

David G. Watt, Stephen T. McSorley, James H. Park, Paul G. Horgan, more

Gastroenterology > 2015 > 148 > 4(S1) > S-1125-S-1126

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Tu1760 Neutrophil Count, but Not Other Components of a White Cell Count, Reflects the Impact of the Systemic Inflammatory Response and Long Term Survival in Patients Following Elective Surgery for Colorectal Cancer

David G. Watt, James H. Park, Michelle L. Ramanathan, Paul G. Horgan, more

Gastroenterology > 2015 > 148 > 4(S1) > S-1175

article

A Retrospective Study of Polyallergy as a Marker of Nonepileptic Seizures in the Epilepsy Monitoring Unit

James H. Park, John Bokma, Kristina Chapple, Jason P. Caplan

Psychosomatics > 2014 > 55 > 6 > 566-571

Distinguishing epileptic seizures from nonepileptic seizures (NES) can be difficult, given their similar motoric manifestations and a common comorbidity. Although video electroencephalography in an epilepsy monitoring unit ideally remains the gold standard for the identification of NES, a number of “soft signs” have been proposed to indicate a greater likelihood that convulsive episodes are NES rather...

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Su1785 Mismatch Repair Status, Host Local and Systemic Inflammatory Responses and Survival in Patients With Primary Operable Colorectal Cancer

James H. Park, Arfon G. Powell, Campbell S. Roxburgh, Colin H. Richards, more

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-1035-S-1036

article

Nogo-66 Receptor Prevents Raphespinal and Rubrospinal Axon Regeneration and Limits Functional Recovery from Spinal Cord Injury

Ji-Eun Kim, Betty P. Liu, James H. Park, Stephen M. Strittmatter

Neuron > 2004 > 44 > 3 > 439-451

Axon regeneration after injury to the adult mammalian CNS is limited in part by three inhibitory proteins in CNS myelin: Nogo-A, MAG, and OMgp. All three of these proteins bind to a Nogo-66 receptor (NgR) to inhibit axonal outgrowth in vitro. To explore the necessity of NgR for responses to myelin inhibitors and for restriction of axonal growth in the adult CNS, we generated ngr ^- ^/ ^-...

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Search results for: James H. Park

The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy

The Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer

The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer

Loss of N‐WASP drives early progression in an Apc model of intestinal tumourigenesis

Clinicopathological Determinants of an Elevated Systemic Inflammatory Response Following Elective Potentially Curative Resection for Colorectal Cancer

In reply to ‘Hynes et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population‐based study’

A Postoperative Systemic Inflammation Score Predicts Short- and Long-Term Outcomes in Patients Undergoing Surgery for Colorectal Cancer

Long-Term Follow-Up of Patients Undergoing Resection of TNM Stage I Colorectal Cancer: An Analysis of Tumour and Host Determinants of Outcome

Neutrophil count is the most important prognostic component of the differential white cell count in patients undergoing elective surgery for colorectal cancer

879 The Validation of C-Reactive Protein and Albumin As Predictors of Post-Operative Infective Complications and Their Clinical Utility in Patients With Colorectal Cancer

Tu1760 Neutrophil Count, but Not Other Components of a White Cell Count, Reflects the Impact of the Systemic Inflammatory Response and Long Term Survival in Patients Following Elective Surgery for Colorectal Cancer

A Retrospective Study of Polyallergy as a Marker of Nonepileptic Seizures in the Epilepsy Monitoring Unit

Su1785 Mismatch Repair Status, Host Local and Systemic Inflammatory Responses and Survival in Patients With Primary Operable Colorectal Cancer

Nogo-66 Receptor Prevents Raphespinal and Rubrospinal Axon Regeneration and Limits Functional Recovery from Spinal Cord Injury

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