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Background & Aims: Interleukin-10 knockout (IL-10 −/− ) mice spontaneously develop colitis characterized by T-helper cell type 1–polarized inflammation. We tested the possible therapeutic activity of the peroxisome proliferator-activated receptor α (PPARα) ligand fenofibrate, and the PPARδ ligand GW0742, in IL-10 −/− mice and investigated the cellular/molecular mechanisms for fenofibrate...