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Cryopreservation is a critical processing step within therapeutic cell manufacturing. As manufacturing processes are scaled-up to achieve commercially-relevant lot sizes, there are several factors to take into account in order to successfully achieve a consistent, highly viable and biologically functional cellular product. Product viability and functionality are dependent upon several downstream processing...
For allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot‐sizes capable of meeting commercial demands of up to 109 cells/dose for large patient numbers due to the current limitations of expansion technologies. This article describes the application...
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