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Background Malaria is a major global cause of deaths and a vaccine is urgently needed. Results We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and estimated affinity (measured as kd) of monoclonal as well as naturally-acquired polyclonal antibodies in human plasma. There were...
Malaria is a disease that kills several million people every year. P. falciparum merozoites invade new erythrocytes every 48h, causing fever, anemia and cerebral malaria. Effective immunity against malaria develops slowly and only after repeated exposure. Antibodies are an important part of this immunity. However, the antigens that mediate immunity by inducing functionally imperative antibodies have...
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