Search results for: Ljudmila Stojanovich

Items from 1 to 19 out of 19 results

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Primary antiphospholipid syndrome and antiphospholipid syndrome associated to systemic lupus: Are they different entities?

Cristina Belizna, Ljudmila Stojanovich, Jan Willem Cohen-Tervaert, Céline Fassot, more

Autoimmunity Reviews > 2018 > 17 > 8 > 739-745

Primary antiphospholipid syndrome (PAPS) and antiphospholipid syndrome associated to lupus (SAPS) have several overlapping characteristics. As systemic manifestations are also reported in patients with PAPS, and as a subgroup of PAPS patients could evaluate to a SAPS, the differentiation between the two types of APS could be performed based on the clinical experience of the medical teams and is related...

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Anti-annexin A5 antibodies and 25-hydroxy-cholecalciferol in female patients with primary antiphospholipid syndrome

Mirjana Bećarević, Marija Sarić, Ljudmila Stojanovich, Duško Mirković, more

Clinical Rheumatology > 2018 > 37 > 12 > 3359-3364

Vascular antiphospholipid syndrome (VAPS) and obstetric (OAPS) are different entities because some patients only develop thrombosis (without recurrent pregnancy losses) and vice versa. Only two articles have reported that low 25-hydroxy-cholecalciferol (vitamin D3, VD3) levels were not correlated with the presence of conventional antiphospholipid antibodies (aPL Abs: anticardiolipin (aCL), anti-beta2glycoprotein...

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Abdominal pain in patient with antiphospholipid syndrome—the role of MDCT angiography on visceral blood vessels

Jovica Saponjski, Ljudmila Stojanovich, Jelena Saponjski, Milorad Mirilovic, more

Immunologic Research > 2017 > 65 > 6 > 1150-1155

Antiphospholipid syndrome (APS) is an autoimmune disease defined by accelerated atherosclerosis, arterial and venous thrombosis, fetal loss, and the presence of antiphospholipid antibodies (aPL) in the serum and which leads to the occurrence of various vascular events. Nonspecific abdominal pain can be one of the symptoms due to changes on visceral blood vessels. The goal of our work is to show the...

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The role of MSCT angiography in early detection of lower limb arterial lesions in patients with antiphospholipid syndrome

Jovica Saponjski, Ljudmila Stojanovich, Jelena Petrovic, Dusan Saponjski

Immunologic Research > 2017 > 65 > 2 > 482-486

Antiphospholipid syndrome (APS) is an autoimmune disease which is characterized by arterial and venous thromboses, fetal loss, and the presence of antiphospholipid antibodies in the serum. It is characterized by accelerated atherosclerosis. Increased tendency towards thrombosis leads to the occurrence of various vascular events. The objective of our study was to determine if there are subclinical...

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Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling

Minesh Kapadia, Dunja Bijelić, Hui Zhao, Donglai Ma, more

Acta Neuropathologica Communications > 2017 > 5 > 1 > 1-24

Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is often accompanied by brain atrophy and diverse neuropsychiatric manifestations of unknown origin. More recently, it was observed that cerebrospinal fluid (CSF) from patients and lupus-prone mice can be neurotoxic and that acute administration of specific brain-reactive autoantibodies (BRAs) can induce deficits in...

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Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome

Dragana Popovic-Kuzmanovic, Ivana Novakovic, Ljudmila Stojanovich, Ivona Aksentijevich, more

Immunobiology > 2013 > 218 > 2 > 186-191

The aim of the study was to investigate serum concentrations of interleukin (IL)-17 and IL-17-inducing cytokines IL-23 and transforming growth factor (TGF)-β, as well as IL-17 single nucleotide polymorphism (SNP) rs2275913 in patients with primary antiphospholipid syndrome (PAPS). We studied fifty patients with PAPS and fifty age- and sex-matched healthy controls. The cytokine levels were measured...

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Toxoplasma gondii: bystander or cofactor in rheumatoid arthritis

Svetlana Fischer, Nancy Agmon-Levin, Yinon Shapira, Bat-Sheva Porat Katz, more

Immunologic Research > 2013 > 56 > 2-3 > 287-292

Parasitic infections may induce variable immunomodulatory effects and control of autoimmune disease. Toxoplasma gondii (T. gondii) is a ubiquitous intracellular protozoan that was recently associated with autoimmunity. This study was undertaken to investigate the seroprevalence and clinical correlation of anti-T. gondii antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus...

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Hyperferritinemia is Associated with Serologic Antiphospholipid Syndrome in SLE Patients

Gisele Zandman-Goddard, Hedi Orbach, Nancy Agmon-Levin, Mona Boaz, more

Clinical Reviews in Allergy & Immunology > 2013 > 44 > 1 > 23-30

Ferritin may play a direct role on the immune system. We sought to determine if elevated levels of ferritin in lupus patients correlate with disease activity and organ involvement in a large cohort. Ferritin levels (gender and age adjusted) were assessed in 274 lupus serum samples utilizing the LIASON Ferritin automated immunoassay method. Significant disease activity was determined if European Consensus...

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Prolactin and Autoimmunity

Hedi Orbach, Gisele Zandman-Goddard, Mona Boaz, Nancy Agmon-Levin, more

Clinical Reviews in Allergy & Immunology > 2012 > 42 > 2 > 189-198

Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort. Age- and sex-adjusted prolactin concentration was assessed in 256 serum samples from lupus patients utilizing the LIASON prolactin automated immunoassay method (DiaSorin S.p.A, Saluggia, Italy). Disease activity...

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Systemic vascular diseases in the antiphospholipid syndrome. What is the best diagnostic choice?

Jovica Saponjski, Ljudmila Stojanovich, A. Djokovic, M. Petkovic, more

Autoimmunity Reviews > 2011 > 10 > 4 > 235-237

Antiphospholipid syndrome (APS) is an autoimmune disease which is characterized by arterial and venous thromboses, fetal loss, and the presence of antiphospholipid antibodies in the serum (aPL). It is characterized by accelerated atherosclerosis and that together with an increased tendency towards thrombosis leading to the occurrence of various vascular events. Timely diagnosis of vascular changes,...

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Stress and autoimmunity

Ljudmila Stojanovich

Autoimmunity Reviews > 2010 > 9 > 5 > A271-A276

The etiology of autoimmune disease is multifactorial, including genetic, environmental, hormonal, and immunological factors. Nevertheless, the onset of autoimmune disorders remains enigmatic. Physical and psychological stresses have been suggested in the development of autoimmune disease, since numerous animal and human studies demonstrated the effect of stressors on immune function. Moreover, many...

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Autonomic dysfunction in autoimmune rheumatic disease

Ljudmila Stojanovich

Autoimmunity Reviews > 2009 > 8 > 7 > 569-572

Cardiovascular and neurological manifestations are known to occur in patients with autoimmune rheumatic disease (ARD), often in subclinical form. The term autonomic nervous system (ANS) describes nerves that are concerned predominantly with the regulation of bodily functions. It is comprised of sympathetic and parasympathetic nerves, and their function is complementary. ANS involvement has rarely...

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Prevalence of hepatitis C serum antibody in autoimmune diseases

Nancy Agmon-Levin, Maya Ram, Ori Barzilai, Bat sheva Porat-Katz, more

Journal of Autoimmunity > 2009 > 32 > 3-4 > 261-266

To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID).We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis...

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Clinical and Laboratory Features of the Catastrophic Antiphospholipid Syndrome

Ljudmila Stojanovich, Dragomir Marisavljevic, Jozef Rovensky, Aleksandra Djokovich, more

Clinical Reviews in Allergy & Immunology > 2009 > 36 > 2-3 > 74-79

Catastrophic antiphospholipid syndrome (CAPS, Asherson’s syndrome) is an unusual form of antiphospholipid syndrome (APS) characterized by multi-organ failure and high mortality. Fortunately, CAPS accounts for less than 1% of APS cases. Due to the rarity of the condition, an international registry of CAPS patients was created in 2000 supported by the European Forum on Antiphospholipid Antibodies held...

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The Catastrophic Antiphospholipid Syndrome in Serbia: Diagnostic and Management Problems

Ljudmila Stojanovich

Clinical Reviews in Allergy & Immunology > 2009 > 36 > 2-3 > 98-103

Antiphospholipid antibodies (aPL) are a common cause of acquired thrombophilia, termed antiphospholipid syndrome (APS, Huges syndrome). Catastrophic antiphospholipid syndrome (CAPS, Asherson’s syndrome) is an unusual form of APS characterized with multi-organ failure and high mortality. Fortunately, CAPS accounts for less than 1% of APS cases. The recurrence rate is low with a stable clinical course...

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Stress as a trigger of autoimmune disease

Ljudmila Stojanovich, Dragomir Marisavljevich

Autoimmunity Reviews > 2008 > 7 > 3 > 209-213

The etiology of autoimmune diseases is multifactorial: genetic, environmental, hormonal, and immunological factors are all considered important in their development. Nevertheless, the onset of at least 50% of autoimmune disorders has been attributed to “unknown trigger factors”. Physical and psychological stress has been implicated in the development of autoimmune disease, since numerous animal and...

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Psychiatric manifestations in systemic lupus erythematosus

Ljudmila Stojanovich, Gisele Zandman-Goddard, Sanja Pavlovich, Natasa Sikanich

Autoimmunity Reviews > 2007 > 6 > 6 > 421-426

Psychiatric abnormalities are common in systemic lupus erythematosus (SLE) with a prevalence of 17% to 75%, reflecting different methods of patient selection and assessment, the different professional orientation of clinicians, and lack of an accepted consensus for diagnosing active neuropsychiatric lupus (NPSLE). The psychiatric syndromes included in the ACR Neuropsychiatric Lupus Nomenclature Committee...

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Ocular manifestations in antiphospholipid syndrome

Gordana Suvajac, Ljudmila Stojanovich, Svetislav Milenkovich

Autoimmunity Reviews > 2007 > 6 > 6 > 409-414

Antiphospholipid syndrome (APS) is characterized by increased hypercoagulability and divergent symptoms including ocular manifestations. In APS patients arterial and/or venous thromboses and repeated fetal loss are diagnosed in presence of antiphospholipid (aPL) antibodies. Antiphospholipid antibodies are heterogeneous group of immunoglobulins with different antigenic structure. Primary APS is defined...

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Pulmonary manifestations in antiphospholipid syndrome

Ljudmila Stojanovich

Autoimmunity Reviews > 2006 > 5 > 5 > 344-348

Pulmonary manifestations in antiphospholipid syndrome (APS) are relatively rare compared to other clinical signs of this disease. However, pulmonary microthrombosis is among the most frequent arterial complications of APS. Timely diagnosis of pulmonary manifestations is required due both to their severity and to the high mortality rate. The spectrum of pulmonary disorders in patients with antiphospholipid...

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